Naturalproductman’s Blog

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Neopeltolide

Posted by naturalproductman on August 7, 2009

Karl Scheidt and co-workers have recently published a full paper in JACS on their account of the synthesis of neopeltolide, a compound isolated from a sponge and also has nanomolar to subnanomolar IC50 values towards cancer cell lines.  The macrocyclic structure that contains a tetrahydropyran ring was formed via a Prins cyclization in one step using scandium triflate.

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JACS paper

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