Naturalproductman’s Blog

Hey, is that a natural product?!

Longipedlactones K−P

Posted by naturalproductman on December 22, 2009

Han-Dong Sun and co-workers at the Chinese Academy of Sciences have recently published in the Journal of Natural Products on the isolation of novel natural pentacyclic products that fall in the triterpene dilactone family of compounds isolated from the stems of Kadsura ananosma.  Longipedlactone J (compound 13) was found to have comparable in vitro cytotoxicity towards HL60 acute leukemia cell lines with cis-platin at 2.0 micromolar IC50 (cis platin had 1.7 micromolar).

longipedlactones

JNP paper

About these ads

One Response to “Longipedlactones K−P”

  1. ILoveChemists said

    So I guess the question is: Is this compound as toxic to the patient as cisplatin? Cisplatin acts by binding and crosslinking DNA, which essentially harms all cells, as you can imagine. Ideallly, one day there will be treatments that can target cancer cells specifically. Great blogging, naturalproductman!

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

 
Follow

Get every new post delivered to your Inbox.

Join 68 other followers

%d bloggers like this: