Naturalproductman’s Blog

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Archive for January, 2010

Fe-Catalyzed C-H Activation

Posted by naturalproductman on January 29, 2010

Christina White’s group at UIUC has been putting forth many efforts towards the area of C-H activation.  Her group’s Science paper just came out on the selectivity issues of iron catalyzed methylene oxidation.  It’s an interesting problem – you have a molecule with multiple -CH2- sites but for some reason the catalyst system selectively always chooses one over the rest.


Science paper

Posted in C-H activation, Iron, Methodology, Transition Metal | Leave a Comment »

Ligulactones A and B

Posted by naturalproductman on January 29, 2010

Some spirosesquiterpenes were isolated by Yan-Ping Shi and co-workers at the Chinese Academy of Sciences.

spirosesquiterpene


JNP paper

Posted in Sesquiterpenes, Spirocycles | Leave a Comment »

Melotenine A

Posted by naturalproductman on January 29, 2010

Melotenine A was isolated by Xiao-Dong Luo and co-workers at the Chinese Academy of Sciences from the plant, Melodinus tenuicaudatus. The pentacyclic alkaloid was found to have 0.9 micromolar IC50 against HL-60 cell lines.

melotenine

OL paper

Posted in Alkaloids, Seven-Membered Rings | Leave a Comment »

Cycloisomerization with Gold

Posted by naturalproductman on January 28, 2010

There have been many advances using gold as a catalyst to make all sorts of cyclic compounds from linear precursors.  Louis Fensterbank and co-workers at CNRS have recetnly published in Chemical Communications on a gold catalyzed cycloisomerization that gives rise to allenyl tetrahydrofuranyl structures.

cycloisomerization

Chem Comm paper

Posted in Allenes, Cascade Reactions, Gold, Methodology, Ring forming, Transition Metal | Leave a Comment »

Ethoxycyclobutanones and Alkenes

Posted by naturalproductman on January 28, 2010

Jun-ichi Matsuo and co-workers at Kanazawa University have recently published on an intramolecular [4+2] cycloaddition to make polycyclic frameworks.

4+2


Chem Comm paper

Posted in Cascade Reactions, Cycloaddition, Methodology, Ring forming | Leave a Comment »

Arisandilactone A

Posted by naturalproductman on January 28, 2010

Arisandilactone A, a new triterpenoid, was reported by Ya-Ching Shen and co-workers at National Taiwan University in Organic Letters.
arisandilactone

OL paper

Posted in Triterpenoids | Leave a Comment »

Cascade Spirocycle

Posted by naturalproductman on January 28, 2010

Seunghoon Shin at Hanyang University have recently published in ACIEE on a gold catalyzed Pinacol-Mannich-Michael reaction to access spirocyclic centers.

cascade


ACIEE paper

Posted in Carbene, Cascade Reactions, Gold, Methodology, Ring forming, Spirocyclic centers, Transition Metal | Leave a Comment »

Ugi Reaction for Isocoumarins

Posted by naturalproductman on January 27, 2010

Stefano Marcaccini and co-workers at the Universita di Firenze have recently published on an Ugi reaction that gives rise to isocoumarins.

isocoumarin

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Named Reactions, Ugi | Leave a Comment »

Three Component Coupling with Alpha-diazo Carbonyl

Posted by naturalproductman on January 27, 2010

Wenhao Hu and co-workers from East China Normal University have recently published on a three component coupling that involves an alpha-diazo compound, alkynyl imino aryl ring and an alcohol in the presence of a dirhodium catalyst and silver triflate.

mcc

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Rhodium, Silver, Transition Metal | Leave a Comment »

Cyanoamidation with Palladium

Posted by naturalproductman on January 27, 2010

Christopher Douglas and co-workers at the University of Minnesota have recently published in Organic Letters on a cyanoamidation reaction using a palladium catalyst.

cyanoamidation

OL paper

****Update****  May 20 2011:

Apparently this paper was withdrawn because the ees were not reproducible.

Posted in C-C Bond Breaking, Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

 
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