Synthesis of Echinopines A and B
Posted by naturalproductman on February 28, 2010
David Chen and co-workers at Institute of Chemical and Engineering Sciences in Singapore have recently published in JACS on the synthesis of echinopines where the key reactions involved the use of an alpha-diazo carbonyl intermediate to afford a cyclopropane ring and an SmI2-mediated intramolecular pinacol coupling between an aldehyde and ketone to form a seven membered ring.
Yi-Ming Shao said
David Chen is being in charge of Nicolaou’s Chemical Synthesis Lab at A*STAR in Singapore. I might have chance to join Chen’s group for my PhD. But so far I am more likely interested in development of organocatalysts. After graduation, I would be happy to join A*STAR, since it is a research institute supported by Singapore government.
naturalproductman said
Wow that is certainly an exciting opportunity! He’s young and I’m absolutely sure that he has many more nice papers to come. Good luck man.