Naturalproductman’s Blog

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Acetogenins

Posted by naturalproductman on April 28, 2010

Yu-Dong Zhou and co-workers from the University of Mississippi have recently reported in the Journal of Natural Products on the isolation of some tetrahydrofuran containing compounds 10-hydroxyglaucanetin, annonacin, and annonacin A, which inhibited hypoxia-induced HIF-1 activation at IC50 values of 12 nM, 13 nM, and 31 nM.

paw paw crude extract

JNP paper

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One Response to “Acetogenins”

  1. Interesting piece of news! Worth sharing among chemists…

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