RRM Strategy for Epihalosaline and Porantheridine

Guillaume Vincent and co-workers at CNRS have published in JOC on a ring rearrangement metathesis (RRM) to access a bicyclic piperidone from a Diels-Alder adduct.  Metathesis is not just about making alkenes anymore.

JOC paper

Phalarine Synthesis

Samuel Danishefsky and co-workers have published in JACS on the total synthesis of phalarine from an amino acid.

JACS paper

Pyrrothines

Ahmed Lebrihi and co-workers at LPBVB in Algeria have published in the Journal of Natural Products on the isolation of new dithiopyrrolone antibiotics after adding valeric acid to Saccharothrix algeriensis culture broth.  Formylpyrrothine had an antimicrobial MIC activity of 2 micrograms/mL against Bacillus subtilis.

JNP paper

Gold Catalyzed Conia-ene Reaction

Paul Davies and co-worker at the University of Birmingham have published in Organic and Biomolecular Chemistry on a gold catalyzed Conia-ene reaction where the presence of water was required for the reaction to occur.

OBC paper

Enantioselective Nazarov using a Thiourea Catalyst

Marcus Tius and co-workers at the University of Hawaii have published in JACS on an organocatalytic enantioselective Nazarov reaction that uses a chiral thiourea catalyst.  The terminal ester seems necessary to activate the substrate.

JACS paper

Gold Catalyzed Desymmetrization

Frank Rominger and co-workers have published in Chemical Communications on a gold catalyzed desymmetrization of a dialkynyl bis furan substrate.

Chem Comm paper

Bryostatin Analog Synthesis

Gary Keck and co-workers at the University of Utah have published in ACIEE on the synthesis of a desoxy bryostatin analog.  They basically removed the hydroxy group on the C-9 position, which is a hydroxy group on a hemiacetal of a tetrahydropyran ring system, by treating a bis-ketal with triethylsilane and TMSOTf.  This selective reduction removed the C-9 oxygen but left in tact the C-19 oxygen.

ACIEE paper

Another Englerin Synthesis

Nicolaou and Chen and co-workers have published on a total synthesis of englerin A in JACS.

JACS paper

Hetero-Diels-Alder

Janusz Jurczak and co-workers at Polish Academy of Sciences have published in Synlett on a hetero-Diels-Alder reaction by using a chromium-Schiff base complex.

Synlett paper

Carboamination via Copper Acetate

Majumdar and co-workers at the University of Kalyani have published in Synlett on a carboamination process catalyzed by copper acetate.

Synlett paper