Syntheses of Largazole and Analogs
Posted by naturalproductman on June 3, 2010
Angel de Lera and co-workers at Universidade de Vigo (Spain) have published in the Journal of Medicinal Chemistry on the syntheses of largazole and its analogs. They further tested their HDAC inhibition.
JMC paper
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This entry was posted on June 3, 2010 at 6:39 am and is filed under Macrocycles, Macrolides, Methodology, Named Reactions, SAR studies.
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Susan Matthew said
Please post the original article
Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.
Taori K, Paul VJ, Luesch H. J Am Chem Soc. 2008 Feb 13;130(6):1806-7.