Cyclizations of 1,5-Enynes with no Metal

Veronique Michelet and co-workers from UMR in Paris have published in Organic Letters on cyclization reactions of 1,5-enynes using NIS.

 

OL paper

Dihypoestoxide Synthesis

Christopher Hayes and co-workers from the University of Nottingham have published in Organic Letters on their progress towards dihypoestoxide.  This molecule if you look closely is a dimer, which can be disconnected to two enone fragments that underwent a hetero-Diels Alder reaction.

OL paper

Copper-Catalyzed O-H Insertion

Qi-Lin Zhou and co-workers from Nankai University have published in JACS on a copper catalyzed asymmetric O-H insertion reaction.

 

JACS paper

Ir-Catalyzed Cyclopropenation

Tsutomu Katsuki and co-workers from Kyushu University have published in JACS on a cyclopropene synthesis from an alkyne.

JACS paper

Didemnaketal Synthesis

Haruhiko Fuwa and co-workers from Tohoku University have published in Organic Letters on a synthesis of didemnaketal which has an IC50 value of 1 micromolar against HIV-1 protease.  The spiroketal unit was accessed from a PPTS catalyzed condensation of an alcohol and a dihydropyran.

 

OL paper

Sn2 with Aldehyde Nucleophiles

Dhar Yadav and co-workers from the University of Allahabad have published in Synlett on an N-heterocyclic carbene catalyzed coupling between an allylic bromide and an aldehyde.

Synlett paper

Rameswaralide Core

Barry Trost and co-workers have published in Tetrahedron Letters on the synthesis of the core of rameswaralide.

TL paper

Ene Reaction with Palladium

Masanari Kimura and co-workers from Nagasaki University have published in JACS on a palladium catalyzed reaction that basically adds an allyl group onto an aldehyde.  The mechanism involves an oxapalladacyclopentane intermediate.

 

JACS paper

Hydroacylation with Rh

Vy Dong and co-workers at the University of Toronto have published in JACS on a rhodium catalyzed hydroacylation where they make a meso cyclopropene compound into a chiral molecule using a Josiphos ligand.

 

JACS paper

Palladium Catalyzed C-H Activation through H-Bonds

Jianliang Xiao and co-workers from the University of Liverpool have published in JACS on a hydrogen bonding promoted C-H activation process.

 

JACS paper