Naturalproductman’s Blog

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Synthesis of Merrilactone

Posted by naturalproductman on October 22, 2010

Michael Greaney and co-workers at the University of Edinburgh have published on the racemic synthesis of merrilactone.  One of the highlights is a radical cascade that involves the use of a titanium reagent on an epoxy alkyne substrate, which undergoes an epoxide opening and a 5-exo dig cyclization.

5 exo

ACIEE paper

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One Response to “Synthesis of Merrilactone”

  1. Edinburgher said

    This one has a funny story behind…anyway

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