Naturalproductman’s Blog

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Archive for January, 2011

Mumbaistatin Analogs

Posted by naturalproductman on January 31, 2011

Hans-Gunther Schmalz and co-workers at the University of Cologne have published in Chemistry a European Journal on a total synthesis of mumbaistatin analogs.

Fries

Chemistry – a European Journal paper

Posted in Cascade Reactions, Fries rearrangement, Methodology, Named Reactions | Leave a Comment »

Vittatalactone Synthesis

Posted by naturalproductman on January 31, 2011

Christoph Schneider and co-workers at Universitat Leipzig have published in Chem Comm on their total synthesis of vittatalactone, which involves an oxy-Cope rearrangement to place the carbons in the correct position with unsaturation followed by an asymmetric reduction to yield the methyls in the correct stereochemical arrangement.

vittatalactone

 

Chem Comm paper

Posted in Cascade Reactions, Cope rearrangement, Iridium, Methodology, Named Reactions, oxy-Cope rearrangement, Pericyclic reactions, Sigmatropic Rearrangements, Transition Metal | Leave a Comment »

Copper Catalyzed Sn2 prime

Posted by naturalproductman on January 31, 2011

Kiyoshi Tomioka and co-workers at Kyoto University have reported in the Journal of Organic Chemistry on a copper N-heterocyclic carbene complex that catalyzes an Sn2 prime reaction.

Sn2 prime

 

JOC paper

Posted in Carbene, Copper, Methodology, Sn2 prime, Transition Metal | Leave a Comment »

TESOTf Catalyzed [4+3]

Posted by naturalproductman on January 31, 2011

Pauline Chiu and colleague at the University of Hong Kong have published in Organic Letters on a [4+3] cycloaddition between a diene and an epoxyenolsilane catalyzed by TESOTf.

4+3

 

OL paper

Posted in Cascade Reactions, Cycloaddition, Methodology, Pericyclic reactions | Leave a Comment »

Iodoarylation with Palladium

Posted by naturalproductman on January 28, 2011

Mark Lautens and co-worker at the University of Toronto have published in JACS on an intramolecular palladium catalyzed iodoarylation reaction.

iodoarylation

 

JACS paper

Posted in Cascade Reactions, Methodology, Palladium, Ring forming, Transition Metal | Leave a Comment »

Double the Rings

Posted by naturalproductman on January 28, 2011

Qun Liu and co-workers at Northeast Normal University have reported in JACS on a cyclization that results in the formation of a pair of heterocyclic rings.

isocyanide

 

JACS paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Organocatalytic | Leave a Comment »

Rhodium Catalyzed C-H Activation

Posted by naturalproductman on January 28, 2011

Frank Glorius and co-workers at Organisch-Chemisches Institut der Westfalischen Wilhelms-Universitat Munster have reported in JACS on a rhodium catalyzed C-H activation process of an aryl ketone in the presence of internal alkynes to form indene structures.

rhodium

 

JACS paper

Posted in C-H activation, Cascade Reactions, Methodology, Rhodium, Transition Metal | Leave a Comment »

All in one flow!

Posted by naturalproductman on January 28, 2011

Timothy Jamison and co-workers have published in ACIEE on a continuous flow reactor way to synthesize nucleic acids.

nucleic acids

 

ACIEE paper

Posted in Methodology, New Setups | Leave a Comment »

The Case of Gold and Heat in the Claisen Rearrangement

Posted by naturalproductman on January 28, 2011

John Macor and co-worker at Bristol Myers Squibb have reported in Tetrahedron Letters on a Claisen rearrangement of a propargyloxyindole.

propargyl

 

TL paper

Posted in Cascade Reactions, Claisen rearrangement, Gold, Methodology, Named Reactions, Pericyclic reactions, Sigmatropic Rearrangements, Transition Metal | Leave a Comment »

Dictyotadimer A

Posted by naturalproductman on January 28, 2011

Gerald Culioli and co-workers at Université du Sud Toulon-Var in France have reported on the isolation of dictyotadimer A, which was isolated in such small quantities that they could not do any biological assays on it.

diterpene

 

TL paper

Posted in Dimer, Diterpene | Leave a Comment »

 
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