Mumbaistatin Analogs

Hans-Gunther Schmalz and co-workers at the University of Cologne have published in Chemistry a European Journal on a total synthesis of mumbaistatin analogs.

Chemistry – a European Journal paper

Vittatalactone Synthesis

Christoph Schneider and co-workers at Universitat Leipzig have published in Chem Comm on their total synthesis of vittatalactone, which involves an oxy-Cope rearrangement to place the carbons in the correct position with unsaturation followed by an asymmetric reduction to yield the methyls in the correct stereochemical arrangement.

 

Chem Comm paper

Copper Catalyzed Sn2 prime

Kiyoshi Tomioka and co-workers at Kyoto University have reported in the Journal of Organic Chemistry on a copper N-heterocyclic carbene complex that catalyzes an Sn2 prime reaction.

 

JOC paper

TESOTf Catalyzed [4+3]

Pauline Chiu and colleague at the University of Hong Kong have published in Organic Letters on a [4+3] cycloaddition between a diene and an epoxyenolsilane catalyzed by TESOTf.

 

OL paper

Iodoarylation with Palladium

Mark Lautens and co-worker at the University of Toronto have published in JACS on an intramolecular palladium catalyzed iodoarylation reaction.

 

JACS paper

Double the Rings

Qun Liu and co-workers at Northeast Normal University have reported in JACS on a cyclization that results in the formation of a pair of heterocyclic rings.

 

JACS paper

Rhodium Catalyzed C-H Activation

Frank Glorius and co-workers at Organisch-Chemisches Institut der Westfalischen Wilhelms-Universitat Munster have reported in JACS on a rhodium catalyzed C-H activation process of an aryl ketone in the presence of internal alkynes to form indene structures.

 

JACS paper

All in one flow!

Timothy Jamison and co-workers have published in ACIEE on a continuous flow reactor way to synthesize nucleic acids.

 

ACIEE paper

The Case of Gold and Heat in the Claisen Rearrangement

John Macor and co-worker at Bristol Myers Squibb have reported in Tetrahedron Letters on a Claisen rearrangement of a propargyloxyindole.

 

TL paper

Dictyotadimer A

Gerald Culioli and co-workers at Université du Sud Toulon-Var in France have reported on the isolation of dictyotadimer A, which was isolated in such small quantities that they could not do any biological assays on it.

 

TL paper