Naturalproductman’s Blog

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Divergolides

Posted by naturalproductman on January 12, 2011

Christian Hertweck and co-workersfrom HKI in Germany have published in ACIEE on the isolation of a group of macrolides and divergolide D was the most cytotoxic with IC50 values ranging from 1-2 micromolar against lung cancer (LXFA 629L), pancreatic cancer (PANC-1), renal cancer (RXF 486L), and sarcoma (Saos-2) cancer cell lines.

divergolides

ACIEE paper

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One Response to “Divergolides”

  1. 1 said

    looks like your post was critical to collect mass for these molecules as targets for synthesis …there 3 or 4 groups that have ventured!

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