Naturalproductman’s Blog

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Archive for February, 2011

Diaryl Ethers from Hypervalent Iodines

Posted by naturalproductman on February 28, 2011

Berit Olofsson and co-workers at Stockholm University have reported in Organic Letters on a hypervalent iodine approach to access diaryl ethers.

diaryl ether

 

OL paper

Posted in Hypervalent Iodine, Methodology | Leave a Comment »

Vinylogous Michael

Posted by naturalproductman on February 28, 2011

Alexandre Alexakis and co-workers at Universite de Geneve in Switzerland have reported in Organic Letters on a vinylogous Michael reaction.

Michael

OL paper

 

Posted in Cascade Reactions, Methodology, Michael, Named Reactions, Organocatalytic | Leave a Comment »

Lactones make enolate surrogates

Posted by naturalproductman on February 28, 2011

Akira Yanagisawa and co-workers at Chiba University have reported in Organic Letters on the use of β,γ-didehydro-γ-lactone as tin-enolate precursors to effect an Aldol reaction.

Aldol

 

OL paper

Posted in Aldol, Asymmetric, C2-Symmetric, Cascade Reactions, Methodology, Named Reactions, Ring forming, Ring Opening | Leave a Comment »

Austocystin D and MDR1

Posted by naturalproductman on February 28, 2011

Henry Pelish and co-workers at Makoto Life Sciences have reported in the Journal Natural Products on the compound, austocystin D, which gets activated by a cytochrome P450 enzyme (CYP3A4) and then does the damage to the cells.

austocystin

 

JNP paper

Posted in Chemical Biology, Flavonoids, Polyketides | Leave a Comment »

Bronstead Acid Catalyzed Cyclization

Posted by naturalproductman on February 28, 2011

Magnus Rueping and co-workers at RWTH Aachen University have reported in JACS on a Bronsted acid catalyzed cyclization of a phenol with an ortho-allylic alcohol substituent to form the ring.

carbocation

 

JACS paper

Posted in Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

[1,5]-Sigmatropic Hydrogen Shift

Posted by naturalproductman on February 27, 2011

Yong-Min Liang and co-workers at Lanzhou University have reported in JOC on a palladium catalyzed 1,5-sigmatropic hydrogen shift to form naphthylamine substrates.

C-H

 

JOC paper

Posted in C-H activation, Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

Cyclobutenones from Allenoates

Posted by naturalproductman on February 27, 2011

Shengming Ma and co-workers at Zhejiang University have reported in JACS on the usefulness of allenoates – you can make cyclobutenones.

cyclobutene

 

JACS paper

Posted in Methodology, Ring forming, Transition Metal, Zinc | Leave a Comment »

Furans to Spiroketals via Singlet Oxygen

Posted by naturalproductman on February 25, 2011

Georgios Vassilikogiannakis and co-workers from the University of Crete report on the light induced spirocyclization reaction of a furan.

spiroketal

OBC paper

Posted in Cascade Reactions, Light Mediated, Methodology, Spirocycles, Spirocyclic centers, Spiroketals | Leave a Comment »

Ageliferin Progress

Posted by naturalproductman on February 25, 2011

Carl Lovely and co-workers at UT Arlington have reported in Organic and Biomolecular Chemistry on their progress towards ageliferin via an intramolecular Diels-Alder reaction.

ageliferin

OBC paper

Posted in Alkaloids, Cascade Reactions, Cycloaddition, Methodology, Pericyclic reactions | Leave a Comment »

Iodine to Fluorinate

Posted by naturalproductman on February 25, 2011

Kazunori Miyamoto and co-workers at the University of Tokushima have reported in Chem Comm on the use of hypervalent iodine-BF4 salt to fluorinate compounds.

iodine

Chem Comm paper

Posted in Cascade Reactions, Hypervalent Iodine, Methodology | Leave a Comment »

 
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