Naturalproductman’s Blog

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Archive for March, 2011

Iron Catalyzed Alkyne-Carbonyl Metathesis

Posted by naturalproductman on March 31, 2011

Umasish Jana and co-workers at Jadavpur University in India have reported in JOC on a iron catalyzed aryl formylation accross an alkyne or as they put it:  an alkyne-carbonyl metathesis reaction.

iron

 

JOC paper

Posted in Cascade Reactions, Iron, Metathesis, Methodology, Transition Metal | Leave a Comment »

Polybromocyclopropene Dienophile

Posted by naturalproductman on March 31, 2011

Dennis Wright and co-worker at the University of Connecticut have reported in Organic Letters on a Diels-Alder cycloaddition between a furan and a polybrominated cyclopropene.

cycloaddition

 

OL paper

Posted in Cascade Reactions, Cycloaddition, Diels-Alder, Methodology, Named Reactions, Pericyclic reactions, Ring forming, Ring Opening | Leave a Comment »

Rubromycin Synthesis

Posted by naturalproductman on March 31, 2011

Thomas Pettus and co-workers have reported in JACS on their synthesis of rubromycin.

rubromycin

 

JACS paper

Posted in Cascade Reactions, Methodology, Polyketides | Leave a Comment »

Hydrovinylation with Ethylene with Ni

Posted by naturalproductman on March 31, 2011

Rajanbabu and co-workers from Ohio State have reported in JACS on a hydrovinylation approach to add an ethylene group accross a substituted alkene using a nickel catalyst.

hydrovinylation

 

JACS paper

Posted in Asymmetric, Cascade Reactions, Methodology, Nickel, Transition Metal | Leave a Comment »

Lithospermic acid synthesis

Posted by naturalproductman on March 29, 2011

Jin-Quan Yu and co-workers at Scripps have reported in JACS on a Pd catalyzed C-H functionalization of an aromatic ring to access lithospermic acid.

lithospermic acid

JACS paper

Posted in C-H activation, Methodology, Palladium, Total Synthesis, Transition Metal | Leave a Comment »

Copper Catalyzed Silyl Ketene Acetal Reaction

Posted by naturalproductman on March 29, 2011

Masaya Sawamura and co-workers at Hokkaido University have reported in JACS on a copper promoted allylic alkylation reaction of a silyl ketene acetal – this reaction was stereospecific.

silyl ketene acetal

JACS paper

Posted in Copper, Methodology, Transition Metal | Leave a Comment »

Thiocillin I Synthesis

Posted by naturalproductman on March 29, 2011

Marco Ciufolini at the University of British Columbia have reported on the total synthesis of thiocillin I.

thiocillin I

JACS paper

Posted in Methodology, Peptides, Total Synthesis | Leave a Comment »

Mangostin Xanthones

Posted by naturalproductman on March 25, 2011

Douglas Kinghorn and co-workers at Ohio State University have reported in the Journal of Natural Products on the isolation of bioactive xanthones.

xanthone

 

JNP paper

Posted in Xanthones | Leave a Comment »

Cupacinoxepin

Posted by naturalproductman on March 25, 2011

Wolfgang Schuehly have reported in the Journal of Natural Products on the isolation of some antimalarial compounds including cupacinoxepin.

anti malarial


JNP paper

Posted in Diseases, Lactones, Malaria, Triterpenes | Leave a Comment »

Basiololide Synthesis

Posted by naturalproductman on March 25, 2011

Brian Stoltz and co-workers at Caltech have reported in ACIEE on a synthesis of basiliolide using a key intramolecular Diels-Alder reaction.

basiliolide

ACIEE paper

Posted in Cascade Reactions, Diels-Alder, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

 
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