Naturalproductman’s Blog

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Archive for April, 2011

Tubulysin mimic

Posted by naturalproductman on April 30, 2011

Ludger Wessjohan and co-workers have reported in JACS on bioactive tubulysin analogs.  One of them had an IC50 value of 0.14 nM against HT-29 cells.

tubulysin

JACS paper

Posted in Methodology, Named Reactions, Peptides, Ugi, Unnatural Products | Leave a Comment »

Ynamide cyclization

Posted by naturalproductman on April 29, 2011

Sebastien Balieu and co-workers at Université Paris Diderot have reported in Tetrahedron Letters on a cyclization using an ynamide substrate.

cyclization

TL paper

Posted in Aromatic, Cascade Reactions, Methodology, Radical Chemistry | Leave a Comment »

Nucleophilic fluoride

Posted by naturalproductman on April 29, 2011

Shuji Akai and co-workers at the University of Shizuoka have reported in Organic Letters on the conversion of a hydroxy group to a fluoro group in a catechol substrate using a nucleophilic fluoride source.

fluoride

OL paper

Posted in Cascade Reactions, Methodology | Leave a Comment »

Ni-cycloaddition

Posted by naturalproductman on April 29, 2011

Janis Louie and co-workers have published in JACS on a nickel catalyzed cyclization of a ketene and a diyne.

nickel

JACS paper

Posted in Cascade Reactions, Cycloaddition, Methodology, Nickel, Pericyclic reactions, Transition Metal | Leave a Comment »

Seven membered rings by opening cyclopropane

Posted by naturalproductman on April 28, 2011

Hans-Gunther Schmalz and co-workers at the Universitat zu Koln have published in the European Journal of Organic Chemistry on the synthesis of some seven membered rings from a cyclopropyl ketone ring opening using a Lewis acid.

Lewis acid

European JOC paper

Posted in Methodology, Ring expansion | Leave a Comment »

Cycloclavine Synthesis

Posted by naturalproductman on April 28, 2011

Peter Wipf and colleague at the University of Pittsburgh have reported on the synthesis of cycloclavine in JACS.

cycloclavine

JACS paper

Posted in Alkaloids, Cycloaddition, Methodology, Pericyclic reactions | Leave a Comment »

Dimerization

Posted by naturalproductman on April 28, 2011

Ji-Kai Liu and co-workers from the Chinese Academy of Sciences have reported in Tetrahedron Letters on a biomimetic synthesis of lindaspirone and bi-linderone.

biomimetic

TL paper

Posted in Methodology, Radical Chemistry | Leave a Comment »

[2+2] via cinchona organocatalyst

Posted by naturalproductman on April 28, 2011

Jieping Zhu and co-workers at CNRS have reported in ACIEE on a [2+2] reaction using a cinchona alkaloid catalyst.

quinine

ACIEE paper

Posted in Allenes, Methodology, Organocatalytic | Leave a Comment »

Ruthenium Catalyzed [2+2]

Posted by naturalproductman on April 28, 2011

Jose Mascarenas and co-workers at CSIC have reported in JACS on a ruthenium catalyzed [2+2] reaction.

2+2

JACS paper

Posted in Cascade Reactions, Methodology, Ruthenium, Transition Metal | Leave a Comment »

Tetracycle from hemp

Posted by naturalproductman on April 27, 2011

Orazio Taglialatela-Scafati and co-workers at Università di Napoli ‘Federico II’ in Italy have reported in Tetrahedron on the isolation of a tetracyclic compound from marijuana – but they called it hemp here.

marijuana

Tetrahedron paper

Posted in Cannabinoids | Leave a Comment »

 
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