Naturalproductman’s Blog

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Archive for October, 2011

Hirsutellone B synthesis

Posted by naturalproductman on October 31, 2011

Hiromi Uchiro and co-workers from Tokyo University of Science have reported in Organic Letters on the total synthesis of hirsutellone.

hirsutellone

OL paper

Posted in Aldol, Alkaloids, Methodology, Named Reactions, Ullman | Leave a Comment »

Acyloxylation with gold

Posted by naturalproductman on October 31, 2011

Veronique Michelet and co-workers at CNRS have reported in JACS on a gold catalyzed C-H activation process.
gold

JACS paper

Posted in C-H activation, Gold, Hypervalent Iodine, Methodology, Transition Metal | Leave a Comment »

Proteomes vs. Disease

Posted by naturalproductman on October 30, 2011

Theo Luider and colleagues at Erasmus Medical Center in the Netherlands have reported in the Journal of Proteome Research on the higher concentration of PZP (Pregnancy Zone Protein) in presymptomatic Alzheimer’s disease group of women.

AD

Journal of Proteome Research paper

Posted in Alzheimer's, Diseases, Peptides, Proteomics | Leave a Comment »

Heparin’s chemoenzymatic synthesis

Posted by naturalproductman on October 28, 2011

Jian Liu and co-workers at UNC have reported in Science on a chemoenzymatic synthesis of the sulfated glycan, heparin – a blood thinner.

 

Science paper

Posted in Chemical Biology, Enzymatic, Glycosides, Methodology | Leave a Comment »

Acetylaranotin synthesis

Posted by naturalproductman on October 28, 2011

Sarah Reisman and co-workers have reported in JACS on a synthesis of acetylaranotin.

1,3-dipolar

JACS paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis, Transition Metal, Ylides | Leave a Comment »

Science careers

Posted by naturalproductman on October 28, 2011

Here’s a Science article about careers in science.
Science article

Posted in Random | Leave a Comment »

[3+2] between aziridine and aldehyde

Posted by naturalproductman on October 28, 2011

Takeshi Hanamoto and co-workers from Saga University have reported in Organic Letters on a AgSbF6 catalyzed [3+2] reaction between an aldehyde and an aziridine.

aziridine

OL paper

Posted in Cascade Reactions, Cycloaddition, Methodology, Pericyclic reactions, Silver, Transition Metal | Leave a Comment »

E or Z is easy

Posted by naturalproductman on October 27, 2011

Shuji Akai and co-workers from the University of Shizuoka have reported in ACIEE on a Meyer Schuster rearrangement that gives rise to selectively the E- or Z-alpha,beta-unsaturated carbonyl compound depending on whether the cationic counterion of the heteropoly acid.

E or Z

ACIEE paper

Posted in Cascade Reactions, Methodology, Meyer-Schuster, Named Reactions, Silver, Transition Metal | Leave a Comment »

Ascorbyl phloroglucinol synthesis

Posted by naturalproductman on October 25, 2011

Shawn Campagna and co-workers at the University of Tennessee in Knoxville have reported in Tetrahedron on a synthesis of ascorbyl phloroglucinol.

glucinol

Tetrahedron paper

Posted in Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Bacteria talking to algae

Posted by naturalproductman on October 25, 2011

Jon Clardy and co-workers at Harvard have reported in JACS on some new molecules isolated from bacteria.

roseobacticides

JACS paper

Posted in Alkaloids, Indoles, Polythio Compounds | Leave a Comment »

 
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