Roseophilin formal synthesis

Junbiao Chang and co-workers at Zhengzhou University have reported in JOC on a formal synthesis of roseophilin.

JOC paper

Tomentosone A

Wilawan Mahabusarakam and co-workers at Songkla University and Griffith University have reported in JOC on the isolation of an antimalarial compound tomentosone A.

Dewar lesions in DNA

Thomas Carrell and co-workers at Ludwig Maximilians University Munich have reported in ACIEE on the mechanistic study of an intramolecular [2+2] reaction at a thymine-phosphate-thymine site, which is prone to undergo UV-damage.

ACIEE paper

Alkaloid syntheses

Xiaoguang Lei and co-workers at Tianjin University have reported in ACIEE on the synthesis of Fawcettimine, Fawcettidine, and 8-Deoxyserratinine.

ACIEE paper

Glyceraldehyde acetonide catalyst for promoting hydroaminations

André Beauchemin and co-workers at the University of Ottawa have reported in JACS on an aldehyde catalyst that promotes hydroaminations.

JACS paper

Pd-catalyzed radical cascade

Erik Alexanian and co-workers have reported in JACS on a synthesis of pyrrolidines from acyclic amines bearing an olefin and iodide.  TEMPO, a stable radical, is used so they propose a radical process although if I didn’t see the TEMPO I would have guessed an oxidative addition followed by carbopalladation and then beta-hydride elimination.

JACS paper

Saxitoxin synthesis

Ryan Looper and colleague have reported in JACS on their synthesis of saxitoxin.

JACS paper

Celastrol and sulfur adducts

Richard Silverman and co-workers at Northwestern have reported in JACS on celastrol as a Michael acceptor.

JACS paper

Kinetic resolution with NHC

Jeffrey Bode and co-workers at ETH Zurich have reported in JACS on a kinetic resolution of cyclic secondary amides using N-heterocyclic carbenes as an organocatalyst.

JACS paper

Angelmarin and columbianetin syntheses

Martin Banwell and co-workers at Australian National University have reported in Tetrahedron Letters on the synthesis of angelmarin.

TL paper