Naturalproductman’s Blog

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Archive for December, 2011

Icumazole synthesis

Posted by naturalproductman on December 30, 2011

Rolf Muller and co-workers have reported in ACIEE on the isolation and total syntheses of icumazoles.

icumazole

ACIEE paper

Posted in Coumarins, Methodology, Oxazoles, Total Synthesis | Leave a Comment »

Fluorinated calystegnine B2

Posted by naturalproductman on December 30, 2011

Jonathan Percy and co-workers at the University of Strathclyde in the UK have reported in JOC on the synthesis of a fluorinated calystegnine B2 analog.

fluorine

JOC paper

Posted in Alkaloids, Computational, DFT, Mechanistic, Methodology, Unnatural Products | Leave a Comment »

Decarbonylative pyridine synthesis

Posted by naturalproductman on December 30, 2011

Karl Hemming and co-workers at the University of Huddersfield in the UK have reported Organic Letters on a neat way to make pyridines.
pyridines

OL paper

Posted in Cascade Reactions, Cycloaddition, Methodology | 2 Comments »

Walsucochinoids

Posted by naturalproductman on December 30, 2011

Jian-Min Yue and co-workers at the Chinese Academy of Sciences have reported in Organic Letters on the isolation of walsucochinoids.

walsucochinoids

OL paper

Posted in Limonoids | Leave a Comment »

Bigunningines

Posted by naturalproductman on December 30, 2011

Yang Ye and co-workers at the Shanghai Institute of Materia Medica have reported in Organic Letters on the isolation of bicunningines, dimeric diterpenoids.

dimer

OL paper

Posted in Dimer, Diterpenoids | Leave a Comment »

Tenuipyrone

Posted by naturalproductman on December 30, 2011

Teigo Asai and co-workers at Tohoku University have reported in Organic Letters on the isolation of tenuipyrone by adding HDAC inhibitor and DNA methyltransferase inhibitors to the culture medium.  Thinking about etymology, it would be funny if the name of this compound came from “tenure” but it actually comes from the name of the fungus they isolated it from…

tenuipyrone

 

OL paper

Posted in Chemical Biology, Polyketides | Leave a Comment »

Magellaninone synthesis

Posted by naturalproductman on December 30, 2011

Richmond Sarpong and colleague have reported in Organic Letters on their progress towards synthesis of magellaninone via a C-H activation protocol.

C-H

OL paper

Posted in Alkaloids, C-H activation, Methodology | Leave a Comment »

Halichondrin C synthesis

Posted by naturalproductman on December 30, 2011

Yoshito Kishi and co-workers have reported in JACS on the synthesis of halichondrin C.

halichondrin C

JACS paper

Posted in Methodology, Polyether, Total Synthesis | Leave a Comment »

Genetic engineering to diversify natural product structures

Posted by naturalproductman on December 30, 2011

Eric Schmidt and co-workers at the University of Utah have reported in JACS on a way to diversify natural products.

ribosomal

JACS paper

Posted in Chemical Biology, Peptides | Leave a Comment »

Oxidative aryltrifluoromethylation

Posted by naturalproductman on December 30, 2011

Guosheng Liu and co-workers at the Chinese Academy of Sciences have reported in JACS on a palladium catalyzed aryl trifluoromethylation cascade.

aryltrifluoromethylation

JACS paper

Posted in Cascade Reactions, Methodology, Palladium, Ring forming, Transition Metal | Leave a Comment »

 
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