Icumazole synthesis

Rolf Muller and co-workers have reported in ACIEE on the isolation and total syntheses of icumazoles.

ACIEE paper

Fluorinated calystegnine B2

Jonathan Percy and co-workers at the University of Strathclyde in the UK have reported in JOC on the synthesis of a fluorinated calystegnine B2 analog.

JOC paper

Decarbonylative pyridine synthesis

Karl Hemming and co-workers at the University of Huddersfield in the UK have reported Organic Letters on a neat way to make pyridines.

OL paper

Walsucochinoids

Jian-Min Yue and co-workers at the Chinese Academy of Sciences have reported in Organic Letters on the isolation of walsucochinoids.

OL paper

Bigunningines

Yang Ye and co-workers at the Shanghai Institute of Materia Medica have reported in Organic Letters on the isolation of bicunningines, dimeric diterpenoids.

OL paper

Tenuipyrone

Teigo Asai and co-workers at Tohoku University have reported in Organic Letters on the isolation of tenuipyrone by adding HDAC inhibitor and DNA methyltransferase inhibitors to the culture medium.  Thinking about etymology, it would be funny if the name of this compound came from “tenure” but it actually comes from the name of the fungus they isolated it from…

 

OL paper

Magellaninone synthesis

Richmond Sarpong and colleague have reported in Organic Letters on their progress towards synthesis of magellaninone via a C-H activation protocol.

OL paper

Halichondrin C synthesis

Yoshito Kishi and co-workers have reported in JACS on the synthesis of halichondrin C.

JACS paper

Genetic engineering to diversify natural product structures

Eric Schmidt and co-workers at the University of Utah have reported in JACS on a way to diversify natural products.

JACS paper

Oxidative aryltrifluoromethylation

Guosheng Liu and co-workers at the Chinese Academy of Sciences have reported in JACS on a palladium catalyzed aryl trifluoromethylation cascade.

JACS paper