Trifluoromethylation with hypervalent iodide
Posted by naturalproductman on February 20, 2012
Zhiqiang Weng and co-workers from Fuzhou University have reported in Tetrahedron on the use of a hypervalent iodide to introduce a trifluoromethyl group on the terminal position of an alkyne.
Dr Jim Romano said
A much easier way is through TMSCF3….CuI, KF…yield I think was very high !!!!
Johnny Bravo said
The method with TMSCF3 requires slow addition of the TMSCF3 while sparging with O2, I believe. It’s an interesting reaction, but I would say it’s not as operationally simple as Weng’s reaction.