Naturalproductman’s Blog

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Archive for March, 2012

Stelletin A

Posted by naturalproductman on March 30, 2012

Wing-Keung Liu and co-workers from the Chinese University of Hong Kong have reported in JNP on the isolation of stellettin A.

stellettin A

JNP paper

Posted in Polyenes | Leave a Comment »

Manoalide vs. HCV

Posted by naturalproductman on March 30, 2012

Nobuyoshi Akimitsu and co-workers from the University of Tokyo have reported on the identification of manoalide A as an inhibitor for heptatitis C virus NS3 helicase.
manoalide

JNP paper

Posted in Diseases, Enzymes, Hepatitis C, Protein Targets, Proteins, Terpenes | Leave a Comment »

Waikialoid A looks like stephacidin

Posted by naturalproductman on March 30, 2012

Robert Cichewicz and co-workers from the University of Oklahoma have reported in JNP on the isolation of waikialoid from Waikiki Beach in Honolulu.
waikialoid

JNP paper

Posted in Alkaloids, Dimer, Polyketides | Leave a Comment »

More on oroidin dimers

Posted by naturalproductman on March 30, 2012

Tadeusz Molinski and co-workers have reported in JNP on the biosynthesis study of benzoscpetrin C and nagelamide H.
oroidin

JNP paper

Posted in Alkaloids, Biosynthesis, Dimer | Leave a Comment »

Virosine A synthesis

Posted by naturalproductman on March 30, 2012

Guillame Belanger and co-workers from the Univerite de Sherbrooke in Canada have reported in JOC on the synthesis of virosine A.
alkaloid

JOC paper

Posted in Alkaloids, Asymmetric, Mannich, Methodology, Named Reactions, Vilsmeier-Haack | Leave a Comment »

Anti-HSV flavonoids

Posted by naturalproductman on March 30, 2012

Xin-Sheng Yao and co-workers from Jinan University have reported on the isolation of some flavonoids  called houttuynoids A-E with anti-Herpes Simplex virus activity (IC50 ~ 45 micromolar).

HSV

OL paper

Posted in Diseases, Flavonoids, Herpes Simplex virus | Leave a Comment »

Oxonium ylide rearrangement mechanism

Posted by naturalproductman on March 30, 2012

Michael Doyle and co-workers have reported in Organic Letters on a mechanistic study of an oxonium ylide rearrangement.
oxonium

OL paper

Posted in Mechanistic | Leave a Comment »

Strychnine syntheses review

Posted by naturalproductman on March 29, 2012

Overman and colleague have reported in ACIE on a review of the literature of the many different ways to make strychnine. Yes it’s true that Woodward originally synthesized this beautiful looking polycycle and that over 50 years later many people are still synthesizing it – one may ask why?  Well if you just compare the efficiencies of the syntheses from decades ago to the current ones, you can see that there is an obvious difference.  From the juxtaposition of the past and present efforts it is clear why synthetic organic chemistry is so important.

Of course that is only one reason why studying organic synthesis is so important.  As my friend LeVar Burton says, “but you don’t have to take my word for it.”
why

ACIE paper

Posted in Alkaloids | Leave a Comment »

Cyrneine A synthesis

Posted by naturalproductman on March 29, 2012

Karl Gademann and co-workers from the University of Basel have reported in ACIE on the synthesis of cyrneine A.  Looking at the structure – 5,6,7-tricycle – I’d say that Nature knows how to count.
cyrneine A

ACIE paper

Posted in Methodology, Seven-Membered Rings, Total Synthesis | Leave a Comment »

Synthesis of axinellamine minus chloride

Posted by naturalproductman on March 29, 2012

Patrick Harran and co-workers in UCLA have reported in ACIE on the racemic synthesis of axinellamine minus the chloride substituent.
axinellamine

ACIE paper

Posted in Alkaloids, Cascade Reactions, Dimer, Methodology | Leave a Comment »

 
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