Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for April, 2012

No that’s not BINAP

Posted by naturalproductman on April 25, 2012

N. P. Dhammika Nanayakkara and co-workers from the University of Mississippi have reported in JNP on the isolation of some compounds that look like BINAP.

antiprotozoal

JNP paper

Posted in Aromatic, C2-Symmetric | Leave a Comment »

Angelone synthesis

Posted by naturalproductman on April 25, 2012

Zhigang Weng and co-workers from Shenzhen University have reported in Tetrahedron on a synthesis of angelone.  The highlight is the cascade reaction forming the final product.

angelone

Tetrahedron paper

Posted in Aromatic, Cascade Reactions, Mechanistic, Methodology, One pot, Total Synthesis | Leave a Comment »

Oxygen transfer

Posted by naturalproductman on April 25, 2012

Yoshihiko Yamamoto and co-workers from Nagoya University have reported in JACS on the formation of a furan from diynes.

sulfur

JACS paper

Posted in Cascade Reactions, Methodology, Ruthenium, Transition Metal | Leave a Comment »

Carboesterification of alkenes

Posted by naturalproductman on April 25, 2012

Huanfeng Jiang and co-workers from South China University of Technology have reported in ACIE on a palladium catalyzed carboesterification of alkenes.

alkyne

ACIE paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

Streptocarbazoles

Posted by naturalproductman on April 25, 2012

Weiming Zhu and co-workers at the Ocean University of China have reported in Organic Letters on the isolation of streptocarbazoles A and B.

streptocarbazoles

OL paper

Posted in Alkaloids, Cancer | Leave a Comment »

Not a sigmatropic rearrangement

Posted by naturalproductman on April 25, 2012

This one looks like a sigmatropic rearrangement but it’s not because it’s missing the sigma bond breaking part, and this reaction also reminds me of the Overman rearrangement.  Shigeo Katsumara and co-workers at Kwansei Gakuin University have reported in Organic Letters on a palladium catalyzed

palladium

OL paper

Posted in Asymmetric, Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

Rhizopodin synthesis

Posted by naturalproductman on April 24, 2012

Dirk Menche and co-workers from Universität Heidelberg have reported in ACIE on the synthesis of rhizopodin.

rhizopodin

ACIE paper

Posted in C2-Symmetric, Macrolides, Methodology, Oxazoles, Total Synthesis | Leave a Comment »

Abyssomicin synthesis

Posted by naturalproductman on April 23, 2012

Radomir Saicic and colleague at the University of Belgrade in Serbia have reported in ACIE on the synthesis of atrop-abyssomicin.

abyssomycin

ACIE paper

Posted in Asymmetric, Cascade Reactions, Chromium, Methodology, Named Reactions, Nickel, Nozaki-Hiyama-Kishi, Total Synthesis, Transition Metal | Leave a Comment »

Selective macrocyclization

Posted by naturalproductman on April 23, 2012

Christopher Boddy and co-workers at the University of Ottawa have reported in Organic Letters on the selective macrocyclization using DEBS TE.

enzyme

OL paper

Posted in Chemical Biology, Enzymatic, Macrocycles, Macrolides, Methodology | Leave a Comment »

Psoromic acid inhibits RabGGTase

Posted by naturalproductman on April 23, 2012

Yao-Wen Wu and co-workers at Max Planck have reported in JACS on the inhibition of RabGGTase using psoromic acid.

psoromic acid

JACS paper

Posted in Aromatic, Cancer, Carboxylic acids, Post-Translational Modification, Protein Targets | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 66 other followers