Naturalproductman’s Blog

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Archive for May, 2012

Aetheramides A and B

Posted by naturalproductman on May 29, 2012

Rolf Mueller and co-workers at Universität des Saarlandes have reported in Organic Letters on some anti-HIV depsipeptides with 15 nM IC50 values.

depsipeptides

OL paper

Posted in Depsipeptides, Diseases, HIV | Leave a Comment »

Benzyne cascade

Posted by naturalproductman on May 11, 2012

Richard Hsung and co-workers at the University of Wisconsin have reported in Organic Letters on a synthesis of chelidonine.

alkaloid

OL paper

Posted in Alkaloids, benzyne, Cascade Reactions, Methodology, Ring forming, Total Synthesis | Leave a Comment »

Bi-mediated [3+2]

Posted by naturalproductman on May 11, 2012

Elisabet Dunac and co-workers from CNRS have reported in Organic Letters on a Bi(OTf)3 mediated [3+2] between an allene and aryl group.

3+2

OL paper

Posted in Allenes, Methodology, Ring forming | Leave a Comment »

Ilicifoliunines A and B

Posted by naturalproductman on May 9, 2012

Vania Santos and co-workers at UNESP in Brazil have reported in JNP on the isolation of some anti-protozoal alkaloids, ilicifoliunines A and B.

anti-protozoal

JNP paper

Posted in Alkaloids, Anti-protozoal, Diseases | Leave a Comment »

Platinum catalyzed dearomatization

Posted by naturalproductman on May 8, 2012

Ken Tanaka and co-workers at Tokyo University of Agriculture and Technology have reported in ACIE on a platinum catalyzed dearomatization reaction.

dearomatization

ACIE paper

Posted in Cascade Reactions, Dearomatization, Diastereoselective, Methodology, Platinum, Transition Metal | Leave a Comment »

Chromium cascade

Posted by naturalproductman on May 8, 2012

Nobuhara Iwasawa and co-workers at Tokyo Institute of Technology have reported in ACIE on a chromium catalyzed cascade.

chromium

ACIE paper

Posted in Cascade Reactions, Chromium, Electrocyclization, Light Mediated, Methodology, Transition Metal | Leave a Comment »

Englerin A formal synthesis

Posted by naturalproductman on May 7, 2012

Kathlynn Parker and colleague have reported in Organic Letters on a formal synthesis of englerin A.

englerin

OL paper

Posted in Cascade Reactions, Metathesis, Methodology, Ruthenium, Sesquiterpenoids, Transition Metal | Leave a Comment »

Merrilactone synthesis

Posted by naturalproductman on May 5, 2012

Hongbin Zhai and co-workers at the Chinese Academy of Sciences have published in ACIE on the synthesis of merrilactone where they used a Pauson-Khand reaction as one of the key steps.

Pauson-Khand

ACIE paper

Posted in Cascade Reactions, Johnson Claisen rearrangement, Methodology, Named Reactions, Neurodegenerative, Pauson-Khand, Triterpenoids | Leave a Comment »

GB-13 synthesis

Posted by naturalproductman on May 3, 2012

David Evans and co-workers have reported in JACS on their synthesis of GB-13.

GB13

JACS paper

Posted in Aldol, Alkaloids, Asymmetric, Methodology, Named Reactions | Leave a Comment »

Ferrier type cascade

Posted by naturalproductman on May 2, 2012

Joseph Kim and co-workers at Sanofi have reported in Tetrahedron Letters on a Ferrier type reaction.

Ferrier

TL paper

Posted in Allenes, Cascade Reactions, Ferrier, Methodology, Named Reactions | Leave a Comment »

 
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