Naturalproductman’s Blog

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Archive for July, 2012

Eliptifoline and ponapensin syntheses

Posted by naturalproductman on July 31, 2012

John Porco and co-workers have reported in JACS on the synthesis of eliptifoline and ponapensin.

photo

JACS paper

Posted in Cascade Reactions, Light Mediated, Methodology, Total Synthesis | Leave a Comment »

Copper Catalyzed C-N Bond Formation

Posted by naturalproductman on July 31, 2012

Nello Mainolfi and co-workers at Novartis have reported in Chemical Science on a copper catalyzed decarboxylative C-N bond forming reaction.

decarboxylative

Chemical Science paper

Posted in Copper, Methodology, Transition Metal | Leave a Comment »

Heronapyrrole C synthesis

Posted by naturalproductman on July 20, 2012

Christian Stark and colleague at the Universitat Hamburg have reported in Organic Letters on the synthesis of heronapyrrole C.

heronapyrrole C

OL paper

Posted in Alkaloids, Asymmetric, Methodology, Tetrahydrofuran, Total Synthesis | Leave a Comment »

Shi epoxidation approach for glabrescol

Posted by naturalproductman on July 20, 2012

Jin Qu and co-workers from Nankai University have reported in Organic Letters on a synthesis of a polytetrahydrofuranyl compound using Shi epoxidation of a polyolefin intermediate.

cascade

OL paper

Posted in Asymmetric, Cascade Reactions, Methodology, Named Reactions, Polyenes, Shi epoxidation, Tetrahydrofuran, Total Synthesis | Leave a Comment »

Lactone and allene radical cyclization

Posted by naturalproductman on July 20, 2012

David Procter and co-workers from the University of Manchester have reported in JACS on a SmI2-mediated radical cyclization of a lactone bearing an allene to form a 5,7-bicyclic ring system.

allene

JACS paper

Posted in Allenes, Methodology, Radical Chemistry, Seven-Membered Rings | Leave a Comment »

Lannotinidine B synthesis

Posted by naturalproductman on July 17, 2012

Zhu-jun Yao and co-workers from Nanjing University have reported in JACS on a synthesis of lannotinidine B.

alkaloid

JACS paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | 1 Comment »

Interrupted Ugi reaction

Posted by naturalproductman on July 16, 2012

Erik Sorensen and co-workers have reported in Chemical Science on their synthesis of 11-methoxy mitragynine.

Ugi

Chemical Science paper

Posted in Alkaloids, Cascade Reactions, Methodology, Named Reactions, Ugi | Leave a Comment »

Gambieric acid A synthesis

Posted by naturalproductman on July 16, 2012

Makoto Sasaki and co-workers at Tohoku University have reported in JACS on the synthesis of gambieric acid A.

gambieric acid A

JACS paper

Posted in Cascade Reactions, Methodology, Polyether | Leave a Comment »

AM-8553 synthesis

Posted by naturalproductman on July 16, 2012

Brian Lucas and co-workers from Amgen in South San Francisco have reported in JACS on the synthesis of AM-8553, which involved some 18O-labeling,
AM-8553

JACS paper

 

Posted in Cancer, Cascade Reactions, Methodology | Leave a Comment »

Isoschizogamine synthesis

Posted by naturalproductman on July 13, 2012

Tohru Fukuyama and co-workers at the University of Tokyo have reported in JACS on the synthesis of isoschizogamine.

isoschizogamine

JACS paper

Posted in Alkaloids, Methodology, Total Synthesis | Leave a Comment »

 
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