Lannotinidine B synthesis
Posted by naturalproductman on July 17, 2012
Zhu-jun Yao and co-workers from Nanjing University have reported in JACS on a synthesis of lannotinidine B.
Posted by naturalproductman on July 17, 2012
Zhu-jun Yao and co-workers from Nanjing University have reported in JACS on a synthesis of lannotinidine B.
AnonV said
The title indicates no protecting groups are used, yet in scheme 2 a hydrogenolysis is conducted to remove the N-benzyl group whose liberated amine undergoes reductive amination to form the 7 membered ring. Is this not considered a protecting group? It seems to me that if NH3 were used in place of benzylamine there would be no ambiguity using the term “protecting group-free” in the title.