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Lannotinidine B synthesis

Posted by naturalproductman on July 17, 2012

Zhu-jun Yao and co-workers from Nanjing University have reported in JACS on a synthesis of lannotinidine B.

alkaloid

JACS paper

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One Response to “Lannotinidine B synthesis”

  1. AnonV said

    The title indicates no protecting groups are used, yet in scheme 2 a hydrogenolysis is conducted to remove the N-benzyl group whose liberated amine undergoes reductive amination to form the 7 membered ring. Is this not considered a protecting group? It seems to me that if NH3 were used in place of benzylamine there would be no ambiguity using the term “protecting group-free” in the title.

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