Naturalproductman’s Blog

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Archive for September, 2012

Chain-walking reaction

Posted by naturalproductman on September 28, 2012

Takuya Kochi and co-workers at Keio University have reported in JACS on a chain walking reaction.

chain

JACS paper

Posted in Methodology, Palladium, Platinum, Ring forming, Transition Metal | Leave a Comment »

Decaturin C synthesis

Posted by naturalproductman on September 19, 2012

Hirosato Takikawa and co-workers at Kobe University have reported in Tetrahedron on the synthesis of decaturin C, a compound with insecticidal properties. I was curious about the hemiketal formation – whether or not the hemiketal is formed completely or it is in equilibrium with the ketone.

decaturin C

Tetrahedron paper

Posted in Methodology, Polyketides, Terpenes, Total Synthesis | Leave a Comment »

IMDA for cyclobutenones

Posted by naturalproductman on September 19, 2012

Danishefsky and co-workers have published in JACS on aan intramolecular Diels-Alder reaction using a cyclobutenone precursor.

cyclobutenone

JACS paper

Posted in Cascade Reactions, Diels-Alder, Methodology, Named Reactions | Leave a Comment »

Communensin F synthesis

Posted by naturalproductman on September 18, 2012

Raymond Funk and colleague at Penn State have reported in JACS on a racemic synthesis of communensin F.

 

JACS paper

Posted in Alkaloids, Methodology, Total Synthesis | Leave a Comment »

Halogen migration

Posted by naturalproductman on September 18, 2012

Jennifer Schomaker and co-workers from the University of Wisconsin have reported in JACS on a copper catalyzed 1,3-halogen migration reaction.

 

JACS paper

Posted in Cascade Reactions, Copper, Methodology, Transition Metal | Leave a Comment »

Polyketide syntheses

Posted by naturalproductman on September 18, 2012

Matthew Shair and co-workers have reported in JACS on the syntheses of some polyketides:  HMP-Y1, hibarimicinone, and HMP-P1.

JACS paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Epicoccin G, 8,8ʹ-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E and Haematocin – total synthesis

Posted by naturalproductman on September 18, 2012

Nicolaou and co-workers have reported in JACS on the syntheses and anti-malarial activities of some polythio compounds.

JACS paper

Posted in Alkaloids, Diseases, Malaria, Methodology, Total Synthesis | Leave a Comment »

Copper catalyzed fluorination

Posted by naturalproductman on September 17, 2012

Thomas Lectka and co-workers at Johns Hopkins University have reported in ACIE on a copper catalyzed fluorination process.

copper

ACIE paper

Posted in C-H activation, Copper, Methodology, Transition Metal | Leave a Comment »

Manganese catalyzed fluorination

Posted by naturalproductman on September 17, 2012

John Groves and co-workers have reported in Science on a manganese promoted fluorination process of aliphatics.

 

Science paper

Posted in C-H activation, Manganese, Methodology, Transition Metal | Leave a Comment »

205B synthesis

Posted by naturalproductman on September 10, 2012

Glenn Micalizio and colleague have reported in JACS on the synthesis of 205B.

205B

JACS paper

Posted in Alkaloids, Methodology, Named Reactions, Sakurai | Leave a Comment »

 
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