Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for October, 2012

Deracemization via ketene dithioacetal intermediate

Posted by naturalproductman on October 30, 2012

Benjamin List and colleague have reported in JACS on a deracemization reaction taking advantage of a ketene-dithioacetal intermediate.

ketene

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology, Organocatalytic | Leave a Comment »

Baeyer-Villiger reaction in the glivocarcin and jadomycin biosynthesis

Posted by naturalproductman on October 30, 2012

Jurgen Rohr and co-workers from the University of Kentucky have reported in JACS on a Baeyer-Villiger reaction in the glivocarcin and jadomycin biosynthesis.

glivocarcin

JACS paper

Posted in Baeyer-Villiger, Biosynthesis, Named Reactions, Polyketides | Leave a Comment »

Asymmetric allylic amination

Posted by naturalproductman on October 29, 2012

Uttam Tambar and colleague at UT Southwestern have reported in JACS on a process involving the allylic amination of terminal olefins using a benzene using a benzenesulfonyl sulfurdiimide reagent.

amination

JACS paper

Posted in Asymmetric, Methodology, Sigmatropic Rearrangements | Leave a Comment »

CPRIT scandalous?

Posted by naturalproductman on October 29, 2012

The big funding agency that is providing the money to recruit Nicolaou to Rice University is in the news spotlight…

Posted in Random | Leave a Comment »

Urushiol detection using a boronate.

Posted by naturalproductman on October 25, 2012

Rebecca Braslau and co-workers published in JOC on the detection of urushiol, the compound in poison ivy that causes the allergic skin rash.

urushiol

JOC paper

Posted in Derivatization, Random | Leave a Comment »

Tubulexin chemical biology

Posted by naturalproductman on October 25, 2012

Herbert Waldmann and co-workers at Max Planck have reported in ACIE on the chemical biology of tubulexins.

tubulexins

ACIE paper

Posted in Cancer, Chemical Biology, Methodology, Protein Targets, Unnatural Products | Leave a Comment »

FD-895 synthesis

Posted by naturalproductman on October 25, 2012

Michael Burkart and James J. La Clair and colleagues at UCSD have reported in Org Lett on the synthesis of

synthesis
OL paper

Posted in Macrolides, Metathesis, Methodology, Polyketides, Ring forming, Ruthenium, Structural Reassignment, Transition Metal | Leave a Comment »

Cyclization through fluorination

Posted by naturalproductman on October 25, 2012

Guosheng Liu and colleague at the Chinese Academy of Science have reported in Org Lett on a fluorination reaction that involves ring formation.
cyclization

OL paper

Posted in Cascade Reactions, Methodology, Ring forming | Leave a Comment »

Mollipilins A and B

Posted by naturalproductman on October 25, 2012

Teigo Asai and co-workers from Tohoku University have reported in Organic Letters on the isolation of mollipilins A and B, which had moderate cytotoxicity against human colon cancer cells at 1.8 and 3.7 micomolar IC50 values.

polyketides

OL paper

Posted in Cancer, colon, Polyketides | Leave a Comment »

Aromatization with palladium

Posted by naturalproductman on October 25, 2012

Naohiko Yoshikai and co-workers from Nanyang Technological University have reported in Organic Letters on the conversion of cyclohexanone to anlines using palladium and 1 atmosphere of oxygen.

aromatization

OL paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 70 other followers