Naturalproductman’s Blog

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Archive for November, 2012

Imidazoles from rhodium

Posted by naturalproductman on November 30, 2012

Jonathan Ellman and co-workers from Yale have reported in ACIE on a rhodium catalyzed reaction to form pyrroles.

rhodium

ACIE paper

Posted in Cascade Reactions, Methodology, Rhodium, Transition Metal | 3 Comments »

Thiophenes from Simmons-Smith

Posted by naturalproductman on November 30, 2012

Kanchugarakoppal Rangappa and co-workers at the University of Mysore in India have reported in Tetrahedron Letters on the synthesis of thiophenes using a Simmons-Smith reagent.

thiophene

TL paper

Posted in Cascade Reactions, Copper, Methodology, Named Reagents, Simmons-Smith, Transition Metal, Zinc | Leave a Comment »

Sulfones to alkenes

Posted by naturalproductman on November 29, 2012

Adrian Schwann and co-workers from the University of Guelph have reported in JOC on a method to convert sulfones to alkenes via a  Ramberg–Bäcklund rearrangement.

olefin

JOC paper

Posted in Cascade Reactions, Methodology, Named Reactions, Ramberg–Bäcklund rearrangement | Leave a Comment »

Oxazoles from cascade

Posted by naturalproductman on November 29, 2012

An-Xin Wu and co-workers from Central China Normal University have published in Tetrahedron on a metal free oxazole synthesis from a methyl ketone and a primary amine.

oxazole

Tetrahedron paper

Posted in Cascade Reactions, Methodology | Leave a Comment »

Importance of basic science

Posted by naturalproductman on November 29, 2012

There is a growing popularity of interdisciplinary research funding, and it seems that many people are forgetting the basic science because basic science seems to be getting less and less money. I would like to point out in Larry Overman’s interview, he talked about how MRI and atmospheric ozone depletion were discovered from basic science and not from interdisciplinary research. So even though many people are trying to become interdisciplinary scientists because that is the trend right now – let’s not forget the importance of knowing one subject really well and being able to contribute to the benefit of society that way one day.

Overman’s interview

Posted in Random | Leave a Comment »

1,4-conjugate addition in water

Posted by naturalproductman on November 28, 2012

Bruce Lipshutz and co-workers have reported in JACS on a organocuprate Michael addition in WATER.

Cu

JACS paper

Posted in Cascade Reactions, Copper, Environmental, Methodology, Transition Metal, Zinc | Leave a Comment »

Aspidophytine synthesis

Posted by naturalproductman on November 27, 2012

Hidetoshi Tokuyama and co-workers from Tohoku University have reported in Tetrahedron on a synthesis of aspidophytine.

alkaloid

Tetrahedron paper

Posted in Alkaloids, Methodology, Total Synthesis | Leave a Comment »

Aspidospermidine from cyclobutanone

Posted by naturalproductman on November 27, 2012

Jun’ichi Matsuo and co-workers from Kanazawa University have reported in ACIE on the synthesis of aspidospermidine.

cyclobutanone

ACIE paper

Posted in Alkaloids, Cascade Reactions, Friedel-Crafts, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

Intramolecular diamination with NIS

Posted by naturalproductman on November 27, 2012

Ulrich Hennecke and co-workers at Westfälische Wilhelms-Universität have reported in Organic Letters on an olefin diamination process using NIS.

diamination

OL paper

Posted in Cascade Reactions, Methodology | Leave a Comment »

Tetarimycin A

Posted by naturalproductman on November 27, 2012

Sean Brady and co-workers from Rockefeller University have reported in JACS on the isolation of tetarimycin A, which had a MIC (minimum inhibitory concentration) of 1.5 micrograms/mL against S. aureus 6538P.

antibiotic

JACS paper

Posted in Antibiotics, Chemical Biology, Polyketides | Leave a Comment »

 
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