Naturalproductman’s Blog

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Archive for December, 2012

ortho-Naphthoquinone methides

Posted by naturalproductman on December 29, 2012

Hironao Sajiki and co-workers from Gifu Pharmaceutical University have reported in ACIE on a generation of naphthoquinone methides using an iron catalyst.

methides
ACIE paper

Posted in Cascade Reactions, Diels-Alder, Iron, Methodology, Named Reactions, Transition Metal | Leave a Comment »

Complanadines A and B syntheses

Posted by naturalproductman on December 29, 2012

Masahiro Hirama and colleagues at Tohoku University have reported in ACIE on the syntheses of complanadines A and B.

complanadines A and B

ACIE paper

Posted in Alkaloids, Methodology, Total Synthesis | Leave a Comment »

Kingianin A synthesis

Posted by naturalproductman on December 29, 2012

Kathlyn Parker and colleague from Stony Brook University have reported in Organic Letters on the synthesis of kingianin A.

kingianin A

OL paper

Posted in Amides, Total Synthesis | Leave a Comment »

pyridines from allenes

Posted by naturalproductman on December 29, 2012

Andrei Yudin and co-workers from the University of Toronto have reported in OL on the synthesis of pyridines from allenes.

pyridines

OL paper

Posted in Allenes, Methodology, Palladium, Transition Metal | Leave a Comment »

Fluevirosines A-C

Posted by naturalproductman on December 29, 2012

Jian-Min Yue and co-workers from the Chinese Academy of Sciences have reported in OL on the isolation of fluevirosines A-C.

fluevirosines A-C

OL paper

Posted in Alkaloids | Leave a Comment »

Siladenoserinols

Posted by naturalproductman on December 29, 2012

Sachiko Tsukamoto and co-workers from Kumamoto University have reported in Organic Letters on the isolation of siladenoserinols A-L, which had inhibitory activity against p53 and HDM2 interaction.

interaction

OL paper

Posted in Cancer, p53, Protein Targets | Leave a Comment »

Nahuoic acid A

Posted by naturalproductman on December 29, 2012

Raymond Andersen and co-workers from the University of British Columbia have reported in Organic Letters on the isolation of nahuoic acid A.

nahuoic acid A

OL paper

Posted in Histone-lysine N-methyltransferase SETD8, Polyketides, Protein Targets | Leave a Comment »

Methyl sarcotroates

Posted by naturalproductman on December 29, 2012

Yue-Wei Guo and co-workers at the Chinese Academy of Sciences have reported in Organic Letters on the isolation of some diterpenoids.

PTPB1

OL paper

Posted in Diterpenoids, Protein Targets, protein tyrosine phosphatase 1B (PTP1B) | Leave a Comment »

Enamine and alkynes to pyrroles

Posted by naturalproductman on December 29, 2012

Lutz Ackermann and colleague at Georg-August-Universität have reported in Organic Letters on the reaction between examines and alkynes to form pyrroles.

pyrroles

OL paper

Posted in Cascade Reactions, Methodology, Ruthenium, Transition Metal | Leave a Comment »

Full report on scholarisine A

Posted by naturalproductman on December 29, 2012

Amos Smith and co-workers published their full paper on scholarisine A synthesis.

scholarisine A

JACS paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

 
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