Aminohydroxylation of alkenes

Hao Xu and co-workers at Georgia State University have reported in JACS on an iron catalyzed aminohydroxylation reaction.

JACS paper

Alkynoates and allylic ethers

Young Ho Rhee and co-workers from Pohang University of Science and Technology have reported in Org Lett on a gold catalyzed coupling of an alkynoate and allylic ether.

OL paper

Radical C-C bond forming/breaking

Samir Zard and colleague at CNRS have reported in JACS on a radical cascade C-C bond forming reaction.

JACS paper

Aminopalladation

Jieping Zhu and co-workers from CNRS have reported in Tetrahedron on an aminopalladation reaction.

Tetrahedron paper

Installation of a nitro group

Debabrata Maiti and co-workers from IIT Bombay have reported in JACS on a way to introduce nitro groups into olefins using TEMPO.

JACS paper

Vegfrecine

Hayamitsu Adachi and co-workers from BIKAKEN have reported in JNP on a novel VEGF receptor tyrosine kinase inhibitor from bacteria. The only problem I see with this compound – from a toxicologist’s perspective – is that this is a quinone, and thus a very reactive electrophile. If this kind of functional group is used as a drug, who knows what other things it will react with in the body – be it DNA, proteins, etc…

JNP paper

Teurilene through epoxide ring opening

Tomas Martin and co-workers from the Universidad de La Laguna in Spain have reported in ACIE on the synthesis of teurilene through an epoxide ring opening cascade.

ACIE paper

Desaturation

C-H bond activation is popular because you can convert alkanes into alcohols – looks like a desaturase reaction where alkanes turn into alkenes is going to be up and coming in popularity soon. Pedro Perez and co-workers at CIQSO in Spain have reported in JACS on a copper catalyst that converted alkanes to alkenes.

 

JACS paper

Towards maoecrystal V

John Chisholm and co-workers from Syracuse University have reported in Tetrahderon Letters on an intramolecular approach towards maeocrystal V.

TL paper

Acutimine synthesis

Seth Herzon and co-workers have published in ACIE on the synthesis of acutimine.

ACIE paper