Naturalproductman’s Blog

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Archive for February, 2013

Aminohydroxylation of alkenes

Posted by naturalproductman on February 27, 2013

Hao Xu and co-workers at Georgia State University have reported in JACS on an iron catalyzed aminohydroxylation reaction.

iron

JACS paper

Posted in Cascade Reactions, Iron, Methodology, Transition Metal | Leave a Comment »

Alkynoates and allylic ethers

Posted by naturalproductman on February 27, 2013

Young Ho Rhee and co-workers from Pohang University of Science and Technology have reported in Org Lett on a gold catalyzed coupling of an alkynoate and allylic ether.

ether

OL paper

Posted in Cascade Reactions, Gold, Mechanistic, Methodology, Sigmatropic Rearrangements, Transition Metal | Leave a Comment »

Radical C-C bond forming/breaking

Posted by naturalproductman on February 27, 2013

Samir Zard and colleague at CNRS have reported in JACS on a radical cascade C-C bond forming reaction.

radical

JACS paper

Posted in Cascade Reactions, Methodology, Radical Chemistry | Leave a Comment »

Aminopalladation

Posted by naturalproductman on February 26, 2013

Jieping Zhu and co-workers from CNRS have reported in Tetrahedron on an aminopalladation reaction.

aminopalladation

Tetrahedron paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

Installation of a nitro group

Posted by naturalproductman on February 26, 2013

Debabrata Maiti and co-workers from IIT Bombay have reported in JACS on a way to introduce nitro groups into olefins using TEMPO.

TEMPO

JACS paper

Posted in Methodology, Radical Chemistry, Silver, Transition Metal | Leave a Comment »

Vegfrecine

Posted by naturalproductman on February 22, 2013

Hayamitsu Adachi and co-workers from BIKAKEN have reported in JNP on a novel VEGF receptor tyrosine kinase inhibitor from bacteria. The only problem I see with this compound – from a toxicologist’s perspective – is that this is a quinone, and thus a very reactive electrophile. If this kind of functional group is used as a drug, who knows what other things it will react with in the body – be it DNA, proteins, etc…
vegfrecine

JNP paper

Posted in Alkaloids, Enzymes, Protein Targets, Proteins | Leave a Comment »

Teurilene through epoxide ring opening

Posted by naturalproductman on February 22, 2013

Tomas Martin and co-workers from the Universidad de La Laguna in Spain have reported in ACIE on the synthesis of teurilene through an epoxide ring opening cascade.

epoxide

ACIE paper

Posted in Cascade Reactions, Methodology, Tetrahydrofuran, Total Synthesis | Leave a Comment »

Desaturation

Posted by naturalproductman on February 21, 2013

C-H bond activation is popular because you can convert alkanes into alcohols – looks like a desaturase reaction where alkanes turn into alkenes is going to be up and coming in popularity soon. Pedro Perez and co-workers at CIQSO in Spain have reported in JACS on a copper catalyst that converted alkanes to alkenes.

 

JACS paper

Posted in C-H activation, Cascade Reactions, Copper, Dehydrogenation, Methodology, Transition Metal | Leave a Comment »

Towards maoecrystal V

Posted by naturalproductman on February 21, 2013

John Chisholm and co-workers from Syracuse University have reported in Tetrahderon Letters on an intramolecular approach towards maeocrystal V.

maoecrystal V

TL paper

Posted in Cycloaddition, Diels-Alder, Methodology, Named Reactions, Pericyclic reactions | Leave a Comment »

Acutimine synthesis

Posted by naturalproductman on February 20, 2013

Seth Herzon and co-workers have published in ACIE on the synthesis of acutimine.

acutimine

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

 
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