Removing triphenylphosphine oxide
Posted by naturalproductman on May 14, 2013
I have had this silly problem in trying to get rid of triphenylphosphine oxide from my reaction mixture. It’s stuck with my final product and can be a pain. Some tricks I’ve seen are the use of dissolving mixture (O=PPh3 and product) in ether and run through short pad of silica. This would be great if my product weren’t so polar – instead my product does not elute with ether. Another trick was from this Lipshutz paper in 2003 where they used Merrifield resin to scavenge the phosphine.