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Archive for the ‘Alkaloids’ Category

Aspeverin synthesis

Posted by naturalproductman on August 30, 2014

Adam Levinson at Sloan Kettering has reported in Organic Letters on the synthesis of aspeverin. Interestingly, Danishefsky was acknowledged for the mentorship but not included in the authors list. I wonder if this is a new kind of way to publish.

aspeverin

OL paper

Posted in Alkaloids, Hypervalent Iodine, Methodology, Total Synthesis | 3 Comments »

Steviol, hetidine, isoatisine syntheses

Posted by naturalproductman on August 30, 2014

Phil Baran and co-workers have reported in JACS on the syntheses of steviol, hetidine, and isoatisine.

alkaloids

JACS paper

Posted in Alkaloids, C-H activation, Methodology, Total Synthesis | Leave a Comment »

Varioxepine A

Posted by naturalproductman on August 28, 2014

Bin-Gui Wang and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of an interesting oxepine containing alkaloid.

oxepine

OL paper

Posted in Alkaloids, Oxepines, Spirocycles | Leave a Comment »

Peganumine A

Posted by naturalproductman on July 27, 2014

Hui-Ming Hua and co-workers from Shenyang Pharmaceutical University have reported in Organic Letters on the isolation of peganumine A, which had an IC50 value of 5.8 μM against HL-60 cells.

peganumine A

OL paper

Posted in Alkaloids, Cancer | Leave a Comment »

Bislactone desymmetrization

Posted by naturalproductman on July 27, 2014

Jieping Zhu and co-workers have reported in ACIE on the synthesis of rhazinilam and leucomidine B.

desymmetrize

ACIE paper

Posted in Alkaloids, Asymmetric, C2-Symmetric, Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Indole alkaloid synthesis

Posted by naturalproductman on July 15, 2014

Corey Stephenson and colleague at the University of Michigan have reported in JACS on the synthesis of pseudotabersonine. A mental roadblock for me was when I was looking at the paper, I was trying to find the structure of catalyst 5, which was the iridium catalyst used for a ring opening reaction, but just found the number 5 in the scheme. Within the text of the paper however it says Ir(dF(CF3)ppy)2(dtbbpy)PF6, which was cited with a Sigma Aldrich catalog number.

 

photoredox

JACS paper

Posted in Alkaloids, Indoles, Iridium, Light Mediated, Methodology, Transition Metal | Leave a Comment »

Cyanogramide

Posted by naturalproductman on July 15, 2014

Weiming Zhu and co-workers at Ocean University of China have reported in Organic Letters on the isolation of cyanogramide.

cyanogramide

OL paper

Posted in Alkaloids, Cancer, Spirocycles | Leave a Comment »

Acanthomanzamines

Posted by naturalproductman on July 15, 2014

Sachiko Tsukamoto and co-workers from Kumamoto University have reported in Organic Letters on the isolation of acanthomanzamines.

acanthomanzamine

OL paper

Posted in Alkaloids | Leave a Comment »

Agelamadins

Posted by naturalproductman on July 15, 2014

More oroidin dimers were isolated – I was reminded of palau’amine.

agelamadins

OL paper

Posted in Alkaloids, Antibiotics | Leave a Comment »

Tetrapetalone A-Me glycon synthesis

Posted by naturalproductman on July 12, 2014

Alison Frontier and co-workers at Rochester University and Hoveyda Boston College have reported in ACIE on the synthesis of tetrapetalone A-Me glycon.

tetrapetalone

 

ACIE paper

Posted in Alkaloids, Methodology, Named Reactions, Nazarov cyclization, Total Synthesis | Leave a Comment »

 
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