Naturalproductman’s Blog

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Archive for the ‘Alkaloids’ Category

Corynoxine synthesis

Posted by naturalproductman on December 18, 2014

Chengfeng Xia and co-workers from the Chinese Academy of Sciences have reported in JACS on the syntheses of corynoxine.

corynoxine

JACS paper

Posted in Alkaloids, Cascade Reactions, Spirocycles, Total Synthesis | Leave a Comment »

Manzacidin A synthesis

Posted by naturalproductman on December 15, 2014

Masayuki Inoue and co-workers at the University of Tokyo have reported in ACIE on the synthesis of manzacidin A.

radical

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Fawcettimine-type alkaloid synthesis

Posted by naturalproductman on December 7, 2014

Gang Zhao and co-workers from the Chinese Academy of Sciences have reported in Tetrahedron on the syntheses of some lycopodium alkaloids.

lycopodium
Tetrahedron paper

Posted in Alkaloids, Total Synthesis, Unified | Leave a Comment »

Lycosperramine-R synthesis

Posted by naturalproductman on December 7, 2014

Hiromitsu Takayama and co-workers from Chiba University have reported in Tetrahedron on the synthesis of lycosperramine R.

lycosperramine

Tetrahedron paper

Posted in Alkaloids, Pyridones, Total Synthesis | 1 Comment »

Combining chemical and enzymatic synthesis

Posted by naturalproductman on November 29, 2014

Kevin Reynolds and co-workers from Portland State University have reported in JOC on the synthesis of premarineosin analogs using a chemo-enzymatic approach.

marineosin

JOC paper

Posted in Alkaloids, Chemical Biology, Enzymatic, Methodology, Total Synthesis, Unnatural Products | 1 Comment »

Perophoramidine synthesis

Posted by naturalproductman on November 29, 2014

Barry Trost and co-workers have reported in Chemical Science on the synthesis of perophoramidine.

perophoramidine

Chemical Science paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Alsmaphorazine D synthesis

Posted by naturalproductman on November 27, 2014

Hanfeng Ding and co-workers have reported in ACIE on the synthesis of alsmaphorazine D.
indole

ACIE paper

Posted in Alkaloids, Indoles, Total Synthesis | Leave a Comment »

Phenolic coupling for morphine

Posted by naturalproductman on November 10, 2014

Matthew Gaunt and co-workers from the University of Cambridge have reported in ACIE on the formal synthesis of morphine through an oxidative phenolic coupling.

morphine

ACIE paper

Posted in Alkaloids, Cascade Reactions, Hypervalent Iodine, Methodology, Total Synthesis | Leave a Comment »

Tetrodotoxin analogs from a newt

Posted by naturalproductman on November 8, 2014

Mari Yotsu-Yamashita and co-workers at Tohoku University have reported in ACIE on the isolation of some tetrodotoxin analogs from a newt.

tetrodotoxin

ACIE paper

Posted in Alkaloids | Leave a Comment »

Disorazole through cross metathesis

Posted by naturalproductman on November 8, 2014

Hoveyda and co-workers from Boston College have reported in JACS on a Z-selective cross coupling to access this C2-symmetric molecule – using alkenyl boronate and alkenyl iodide moieties.
metathesis

JACS paper

Posted in Alkaloids, C2-Symmetric, Metathesis, Methodology, Oxazoles, Ruthenium, Transition Metal | Leave a Comment »

 
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