Naturalproductman’s Blog

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Archive for the ‘Alkaloids’ Category

Indole alkaloid synthesis

Posted by naturalproductman on July 15, 2014

Corey Stephenson and colleague at the University of Michigan have reported in JACS on the synthesis of pseudotabersonine. A mental roadblock for me was when I was looking at the paper, I was trying to find the structure of catalyst 5, which was the iridium catalyst used for a ring opening reaction, but just found the number 5 in the scheme. Within the text of the paper however it says Ir(dF(CF3)ppy)2(dtbbpy)PF6, which was cited with a Sigma Aldrich catalog number.

 

photoredox

JACS paper

Posted in Alkaloids, Indoles, Iridium, Light Mediated, Methodology, Transition Metal | Leave a Comment »

Cyanogramide

Posted by naturalproductman on July 15, 2014

Weiming Zhu and co-workers at Ocean University of China have reported in Organic Letters on the isolation of cyanogramide.

cyanogramide

OL paper

Posted in Alkaloids, Cancer, Spirocycles | Leave a Comment »

Acanthomanzamines

Posted by naturalproductman on July 15, 2014

Sachiko Tsukamoto and co-workers from Kumamoto University have reported in Organic Letters on the isolation of acanthomanzamines.

acanthomanzamine

OL paper

Posted in Alkaloids | Leave a Comment »

Agelamadins

Posted by naturalproductman on July 15, 2014

More oroidin dimers were isolated – I was reminded of palau’amine.

agelamadins

OL paper

Posted in Alkaloids, Antibiotics | Leave a Comment »

Tetrapetalone A-Me glycon synthesis

Posted by naturalproductman on July 12, 2014

Alison Frontier and co-workers at Rochester University and Hoveyda Boston College have reported in ACIE on the synthesis of tetrapetalone A-Me glycon.

tetrapetalone

 

ACIE paper

Posted in Alkaloids, Methodology, Named Reactions, Nazarov cyclization, Total Synthesis | Leave a Comment »

Gracilamine synthesis

Posted by naturalproductman on July 12, 2014

Shuanhu Gao and co-workers at East China Normal University have reported in ACIE on the synthesis of gracilamine.
alkaloid

ACIE paper

 

Posted in Alkaloids, Mannich, Methodology, Michael, Named Reactions, Nazarov cyclization, Total Synthesis | Leave a Comment »

Sespinine synthesis

Posted by naturalproductman on June 28, 2014

Ang Li and co-workers from SIOC have reported in ACIE on the synthesis of sespinine.
sespinine

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Psiloborine A synthesis

Posted by naturalproductman on June 28, 2014

Scott Snyder and co-workers at Columbia and now Scripps have reported in JACS on the synthesis of psiloborine A.
psiloborine A

 

JACS paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Zoaramine

Posted by naturalproductman on June 3, 2014

Antonio Hernandez Daranas and co-workers at University La Laguna in Spain have reported in Organic Letters on the isolation of zoaramine.
zoaramine

OL paper

Posted in Alkaloids, Osteoporosis | Leave a Comment »

So they made the trophy target, now what?

Posted by naturalproductman on May 29, 2014

Did you ever wonder what happened to palau’amine after they synthesized it? Was it the end of the story there? Well they did publish in the Journal of Natural Products in 2012 on the target of palau’amine and it was an inhibitor for the human 20S proteasome. You may wonder what the proteasome does:  it just degrades proteins (broken down or not needed) through proteolysis. Is that exciting? Well that may be a subjective question. It may be like saying is Coke delicious?

 

JNP paper

 

Posted in Alkaloids, Chemical Biology, Elucidation of natural product bioactivity, Protein Targets | Leave a Comment »

 
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