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Archive for the ‘Alkaloids’ Category

Phenolic coupling for morphine

Posted by naturalproductman on November 10, 2014

Matthew Gaunt and co-workers from the University of Cambridge have reported in ACIE on the formal synthesis of morphine through an oxidative phenolic coupling.

morphine

ACIE paper

Posted in Alkaloids, Cascade Reactions, Hypervalent Iodine, Methodology, Total Synthesis | Leave a Comment »

Tetrodotoxin analogs from a newt

Posted by naturalproductman on November 8, 2014

Mari Yotsu-Yamashita and co-workers at Tohoku University have reported in ACIE on the isolation of some tetrodotoxin analogs from a newt.

tetrodotoxin

ACIE paper

Posted in Alkaloids | Leave a Comment »

Disorazole through cross metathesis

Posted by naturalproductman on November 8, 2014

Hoveyda and co-workers from Boston College have reported in JACS on a Z-selective cross coupling to access this C2-symmetric molecule – using alkenyl boronate and alkenyl iodide moieties.
metathesis

JACS paper

Posted in Alkaloids, C2-Symmetric, Metathesis, Methodology, Oxazoles, Ruthenium, Transition Metal | Leave a Comment »

Plakinamines N and O

Posted by naturalproductman on November 4, 2014

Kirk Gustafson and co-workers from the NCI have reported in JNP on the isolation of plakinamines N and O.
plakinamine

JNP paper

Posted in Alkaloids, Cancer, colon, Steroids | Leave a Comment »

Alkaloid syntheses

Posted by naturalproductman on November 4, 2014

Xiaoguang Lei and co-workers from Tianjin University have reported in ACIE on the syntheses of huperzine and lycopladines.

alkaloids

ACIE paper

Posted in Alkaloids, Methodology, Total Synthesis | Leave a Comment »

Sarpagine alkaloids synthesis

Posted by naturalproductman on November 4, 2014

Tanja Gaich and co-worker from Leibniz University of Hannover have reported in ACIE on the synthesis of sarpagine alkaloids.

alkaloid

ACIE paper

Posted in Alkaloids, Methodology, Total Synthesis | Leave a Comment »

Axinellamines A and B

Posted by naturalproductman on October 25, 2014

When I saw the abstract figure, I wasn’t surprised to see that this paper came from Phil Baran’s group.

axinellamines

JACS paper

Posted in Alkaloids, Methodology, Total Synthesis | Leave a Comment »

Haouamine B pentaacetate synthesis

Posted by naturalproductman on October 11, 2014

Hidetoshi Tokuyama and co-workers from Tohoku University have reported in ACIE on the synthesis of haouamine B pentaacetate.

haouamine B

ACIE paper

Posted in Alkaloids, Structural Reassignment, Total Synthesis | Leave a Comment »

Hapalindole alkaoid syntheses

Posted by naturalproductman on October 11, 2014

Ang Li and co-workers from SIOC have reported in ACIE on the syntheses of hapalindole compounds.

hapalindole

ACIE paper

Posted in Alkaloids, Indoles, Total Synthesis | Leave a Comment »

N-methylwelwitindolinone B isothiocyanate synthesis

Posted by naturalproductman on October 11, 2014

Neil Garg and co-workers reported the synthesis of N-methylwelwitindolinone B isothiocyanate in JACS.

alkaloid

JACS paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

 
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