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Archive for the ‘Alkaloids’ Category

Varioxepine A

Posted by naturalproductman on August 28, 2014

Bin-Gui Wang and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of an interesting oxepine containing alkaloid.

oxepine

OL paper

Posted in Alkaloids, Oxepines, Spirocycles | Leave a Comment »

Peganumine A

Posted by naturalproductman on July 27, 2014

Hui-Ming Hua and co-workers from Shenyang Pharmaceutical University have reported in Organic Letters on the isolation of peganumine A, which had an IC50 value of 5.8 μM against HL-60 cells.

peganumine A

OL paper

Posted in Alkaloids, Cancer | Leave a Comment »

Bislactone desymmetrization

Posted by naturalproductman on July 27, 2014

Jieping Zhu and co-workers have reported in ACIE on the synthesis of rhazinilam and leucomidine B.

desymmetrize

ACIE paper

Posted in Alkaloids, Asymmetric, C2-Symmetric, Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Indole alkaloid synthesis

Posted by naturalproductman on July 15, 2014

Corey Stephenson and colleague at the University of Michigan have reported in JACS on the synthesis of pseudotabersonine. A mental roadblock for me was when I was looking at the paper, I was trying to find the structure of catalyst 5, which was the iridium catalyst used for a ring opening reaction, but just found the number 5 in the scheme. Within the text of the paper however it says Ir(dF(CF3)ppy)2(dtbbpy)PF6, which was cited with a Sigma Aldrich catalog number.

 

photoredox

JACS paper

Posted in Alkaloids, Indoles, Iridium, Light Mediated, Methodology, Transition Metal | Leave a Comment »

Cyanogramide

Posted by naturalproductman on July 15, 2014

Weiming Zhu and co-workers at Ocean University of China have reported in Organic Letters on the isolation of cyanogramide.

cyanogramide

OL paper

Posted in Alkaloids, Cancer, Spirocycles | Leave a Comment »

Acanthomanzamines

Posted by naturalproductman on July 15, 2014

Sachiko Tsukamoto and co-workers from Kumamoto University have reported in Organic Letters on the isolation of acanthomanzamines.

acanthomanzamine

OL paper

Posted in Alkaloids | Leave a Comment »

Agelamadins

Posted by naturalproductman on July 15, 2014

More oroidin dimers were isolated – I was reminded of palau’amine.

agelamadins

OL paper

Posted in Alkaloids, Antibiotics | Leave a Comment »

Tetrapetalone A-Me glycon synthesis

Posted by naturalproductman on July 12, 2014

Alison Frontier and co-workers at Rochester University and Hoveyda Boston College have reported in ACIE on the synthesis of tetrapetalone A-Me glycon.

tetrapetalone

 

ACIE paper

Posted in Alkaloids, Methodology, Named Reactions, Nazarov cyclization, Total Synthesis | Leave a Comment »

Gracilamine synthesis

Posted by naturalproductman on July 12, 2014

Shuanhu Gao and co-workers at East China Normal University have reported in ACIE on the synthesis of gracilamine.
alkaloid

ACIE paper

 

Posted in Alkaloids, Mannich, Methodology, Michael, Named Reactions, Nazarov cyclization, Total Synthesis | Leave a Comment »

Sespinine synthesis

Posted by naturalproductman on June 28, 2014

Ang Li and co-workers from SIOC have reported in ACIE on the synthesis of sespinine.
sespinine

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

 
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