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Archive for the ‘alpha-pyrones’ Category

Alpha-pyrone access with gold

Posted by naturalproductman on May 2, 2011

Stuart Schreiber and co-workers have reported in Organic Letters on a gold catalyzed coupling of alkynes and propiolic acids to access alpha-pyrones.

alpha-pyrones

OL paper

Posted in alpha-pyrones, Cascade Reactions, Gold, Methodology, Transition Metal | Leave a Comment »

Beta-Lactone to Alpha-Pyrone

Posted by naturalproductman on November 11, 2010

Patrick Pale and co-workers from CNRS have published in Organic Letters on a gold catalyzed cycloisomerization of a beta-alkynylpropiolactone to furnish an alpha-pyrone ring. This is an extension of the cycloisomerization reaction of an epoxy-alkyne to a furan ring.

cycloisomerization

 

OL paper

Posted in alpha-pyrones, Cascade Reactions, Gold, Methodology, Transition Metal | Leave a Comment »

Angelmarin Synthesis

Posted by naturalproductman on May 25, 2009

Mark J. Coster in the University of Queensland in Australia has come up with a very nice synthesis of angelmarin (racemic).  The activity is 0.01 micrograms/mL towards PANC-1 cells.

angelmarin

JOC paper

Posted in alpha-pyrones, Aromatic | Leave a Comment »

Myxopyronin A an RNA polymerase inhibitor

Posted by naturalproductman on March 18, 2009

This article in ACIEE explains the Cell paper on how myxopyronin A inhibits an RNA polymerase from a bacteria that causes tuberculosis.

xray structure

ACIEE paper

Cell paper

Posted in alpha-pyrones, Antibiotics | Leave a Comment »

 
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