Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Amino Acids’ Category

Aspergillomarasmine A

Posted by naturalproductman on June 28, 2014

Gerald Wright and co-workers from McMaster University in Canada have reported in Nature on aspergillomarasmine A being a good inhibitor for the New Dehli Metallo beta-lactamase 1 (NDM-1) enzyme.

 

Nature paper

Posted in Amino Acids, Antibiotics, Diseases | 1 Comment »

Cyanobacteriochromes

Posted by naturalproductman on April 19, 2012

Clark Lagarias and co-workers at UC Davis have reported in UC Davis on the study of cyanobacteriochromes, proteins that sense light.

cyanobacteriochromes

Biochemistry paper

Posted in Amino Acids, Pyrroles | Leave a Comment »

Proline coupling

Posted by naturalproductman on February 15, 2012

Danishefsky and co-workers have reported in JACS on a proline cross-linking reaction that involves a diselenide precursor.

selenide

JACS paper

Posted in Amino Acids, Cascade Reactions, Methodology | Leave a Comment »

Sudden Unexpected Death now explained

Posted by naturalproductman on February 10, 2012

Ji-Kai Liu and co-workers have reported in ACIEE on toxic amino acids found in a mushroom.

amino acid

ACIEE paper

Posted in Amino Acids | Leave a Comment »

Pleurocybellaziridine

Posted by naturalproductman on December 25, 2010

First things first:  Merry Christmas!  Happy holidays!

Toshiyuki Kan and co-workers from the University of Shizuoka have published in ACIEE on the evidence of an aziridine containing amino acid in a fungus called Angel’s wing.  They did some detective work because the aziridine containing amino acid dubbed pleurocybellaziridine is not stable enough for observation.  The carboxylic acid was not stable so they derivitized the natural product to the methyl ester form, which was more stable.  They also synthesized the aziridine containing amino acid to confirm the structures through spectral data.  The aziridine was synthesized via Mitsunobu conditions.  Interestingly the carboxylic acid form is more cytotoxic (87 micromolar, strong activity) compared to the methyl ester (233 micromolar, weak activity).  Pleurocybellaziridine damages the oligodendrocytes, which makes up the myelin sheath in the brain.

angel's wing

ACIEE paper

Posted in Amino Acids, Methodology, Mitsunobu, Named Reactions | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 68 other followers