Naturalproductman’s Blog

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Archive for the ‘Aromatic’ Category

Linoxepin synthesis

Posted by naturalproductman on April 18, 2013

Mark Lautens and co-workers at the University of Toronto have reported in ACIE on the synthesis of linoxepin.

linoxepin

ACIE paper

Posted in Aromatic, Polyketides, Total Synthesis | Leave a Comment »

Calvicularin synthesis

Posted by naturalproductman on January 10, 2013

Christopher Beaudry and co-workers from Oregon State have reported in Organic Letters on a synthesis of cavicularin using a vinyl sulfone for a Diels-Alder substrate.

calvicularin

OL paper

Posted in Aromatic, Cascade Reactions, Diels-Alder, Methodology, Named Reactions, Polyketides | Leave a Comment »

HIV-1 reverse transcriptase structure with catechol diether

Posted by naturalproductman on November 19, 2012

Karen Anderson and co-workers at Yale have reported in JACS on a crystal structures of HIV-1 reverse transcriptase with catechol diether drugs.

HIV

JACS paper

Posted in Aromatic, Diseases, Enzymes, HIV, Proteins | Leave a Comment »

Xestoquinones

Posted by naturalproductman on September 7, 2012

Daniel Nagle and co-workers from the University of Mississippi have reported in JNP on the isolation of xestoquinones.

xestoquinones

JNP paper

Posted in Aromatic, breast, Cancer | Leave a Comment »

No that’s not BINAP

Posted by naturalproductman on April 25, 2012

N. P. Dhammika Nanayakkara and co-workers from the University of Mississippi have reported in JNP on the isolation of some compounds that look like BINAP.

antiprotozoal

JNP paper

Posted in Aromatic, C2-Symmetric | Leave a Comment »

Angelone synthesis

Posted by naturalproductman on April 25, 2012

Zhigang Weng and co-workers from Shenzhen University have reported in Tetrahedron on a synthesis of angelone.  The highlight is the cascade reaction forming the final product.

angelone

Tetrahedron paper

Posted in Aromatic, Cascade Reactions, Mechanistic, Methodology, One pot, Total Synthesis | Leave a Comment »

Psoromic acid inhibits RabGGTase

Posted by naturalproductman on April 23, 2012

Yao-Wen Wu and co-workers at Max Planck have reported in JACS on the inhibition of RabGGTase using psoromic acid.

psoromic acid

JACS paper

Posted in Aromatic, Cancer, Carboxylic acids, Post-Translational Modification, Protein Targets | Leave a Comment »

Baccharin

Posted by naturalproductman on April 19, 2012

Satoshi Endo and co-workers from Gifu Pharmaceutical University have reported in JNP on the isolation of baccharin a 17-beta-hydroxysteroid dehydrogenase inhibitor.

baccharin

JNP paper

Posted in Aromatic, breast, Cancer, prostate | Leave a Comment »

Rocaglamide via Nazarov

Posted by naturalproductman on March 29, 2012

Phil Magnus and co-workers have published in JACS on a Nazarov cyclization approach to access rocaglamide.
rocaglamide

JACS paper

Posted in Aromatic, Methodology, Named Reactions, Nazarov cyclization | Leave a Comment »

Phaeosphaerins A-F

Posted by naturalproductman on February 10, 2012

Hongxiang Lou and co-workers from Shandong University have reported in JNP on the isolation of phaeosphaerins that were more potent against cancer cells in the presence of light.

phaeosphaerins

JNP paper

Posted in Aromatic, Cancer | Leave a Comment »

 
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