Mark Lautens and co-workers at the University of Toronto have reported in ACIE on the synthesis of linoxepin.

Posted by naturalproductman on April 18, 2013
Mark Lautens and co-workers at the University of Toronto have reported in ACIE on the synthesis of linoxepin.

Posted in Aromatic, Polyketides, Total Synthesis | Leave a Comment »
Posted by naturalproductman on January 10, 2013
Christopher Beaudry and co-workers from Oregon State have reported in Organic Letters on a synthesis of cavicularin using a vinyl sulfone for a Diels-Alder substrate.

Posted in Aromatic, Cascade Reactions, Diels-Alder, Methodology, Named Reactions, Polyketides | Leave a Comment »
Posted by naturalproductman on November 19, 2012
Karen Anderson and co-workers at Yale have reported in JACS on a crystal structures of HIV-1 reverse transcriptase with catechol diether drugs.

Posted in Aromatic, Diseases, Enzymes, HIV, Proteins | Leave a Comment »
Posted by naturalproductman on September 7, 2012
Daniel Nagle and co-workers from the University of Mississippi have reported in JNP on the isolation of xestoquinones.

Posted in Aromatic, breast, Cancer | Leave a Comment »
Posted by naturalproductman on April 25, 2012
N. P. Dhammika Nanayakkara and co-workers from the University of Mississippi have reported in JNP on the isolation of some compounds that look like BINAP.

Posted in Aromatic, C2-Symmetric | Leave a Comment »
Posted by naturalproductman on April 25, 2012
Zhigang Weng and co-workers from Shenzhen University have reported in Tetrahedron on a synthesis of angelone. The highlight is the cascade reaction forming the final product.

Posted in Aromatic, Cascade Reactions, Mechanistic, Methodology, One pot, Total Synthesis | Leave a Comment »
Posted by naturalproductman on April 23, 2012
Yao-Wen Wu and co-workers at Max Planck have reported in JACS on the inhibition of RabGGTase using psoromic acid.

Posted in Aromatic, Cancer, Carboxylic acids, Post-Translational Modification, Protein Targets | Leave a Comment »
Posted by naturalproductman on April 19, 2012
Satoshi Endo and co-workers from Gifu Pharmaceutical University have reported in JNP on the isolation of baccharin a 17-beta-hydroxysteroid dehydrogenase inhibitor.

Posted in Aromatic, breast, Cancer, prostate | Leave a Comment »
Posted by naturalproductman on March 29, 2012
Phil Magnus and co-workers have published in JACS on a Nazarov cyclization approach to access rocaglamide.

Posted in Aromatic, Methodology, Named Reactions, Nazarov cyclization | Leave a Comment »
Posted by naturalproductman on February 10, 2012
Hongxiang Lou and co-workers from Shandong University have reported in JNP on the isolation of phaeosphaerins that were more potent against cancer cells in the presence of light.

Posted in Aromatic, Cancer | Leave a Comment »