Looking at this molecule, one would never think that you can mix three things, a penta-substituted benzene ring, benzaldehyde and humulene, and obtain the final compound, guajadial! Ji-Kai Liu and co-workers at the Kunming Institute of Botany did such a thing!
Archive for the ‘Biosynthesis’ Category
Posted by naturalproductman on November 21, 2012
Posted by naturalproductman on October 30, 2012
Jurgen Rohr and co-workers from the University of Kentucky have reported in JACS on a Baeyer-Villiger reaction in the glivocarcin and jadomycin biosynthesis.
Posted by naturalproductman on April 20, 2012
Hideaki Oikawa and co-workers at Hokkaido University have reported in JACS on a sequential epoxidation of a bis olefin compound to yield a diepoxide that undergoes a ring opening cascade to form two cyclic polyethers (a tetrahydropyran and tetrahydrofuran).
Posted by naturalproductman on March 30, 2012
Tadeusz Molinski and co-workers have reported in JNP on the biosynthesis study of benzoscpetrin C and nagelamide H.
Posted by naturalproductman on December 2, 2011
Andreas Kirschning and co-workers at have reported in ACIEE on a combined biosynthesis/chemical synthesis approach to synthesize new ansamitocin analogs.
Posted by naturalproductman on November 19, 2011
Vahe Bandarian and colleague at the University of Arizona have reported in Biochemistry on the biosynthetic study of demethylwyosine.
Posted by naturalproductman on August 22, 2011
Steven Van Lanen and co-workers from the University of Kentucky have reported in JACS on the biosynthetic studies of the aminoribosyl functional groups in peptidyl ribosyl natural products.
Posted by naturalproductman on May 27, 2011
Jon Clardy and co-workers at Harvard have reported in Organic Letters on the isolation of some compounds by deleting certain genes in B. thailandensis.
Posted by naturalproductman on May 24, 2011
Georg Pohnert and co-workers from Friedrich Schiller University have reported in Organic Letters on the biosynthesis of a conjugated allene found in the biosynthetic pathway of moss Dicranum scoparium.