Multi-component approach to guajadial B

Looking at this molecule, one would never think that you can mix three things, a penta-substituted benzene ring, benzaldehyde and humulene, and obtain the final compound, guajadial! Ji-Kai Liu and co-workers at the Kunming Institute of Botany did such a thing!

OL paper

Baeyer-Villiger reaction in the glivocarcin and jadomycin biosynthesis

Jurgen Rohr and co-workers from the University of Kentucky have reported in JACS on a Baeyer-Villiger reaction in the glivocarcin and jadomycin biosynthesis.

JACS paper

Diepoxide intermediate

Hideaki Oikawa and co-workers at Hokkaido University have reported in JACS on a sequential epoxidation of a bis olefin compound to yield a diepoxide that undergoes a ring opening cascade to form two cyclic polyethers (a tetrahydropyran and tetrahydrofuran).

JACS paper

More on oroidin dimers

Tadeusz Molinski and co-workers have reported in JNP on the biosynthesis study of benzoscpetrin C and nagelamide H.

JNP paper

Chemical synthesis with biosynthesis

Andreas Kirschning and co-workers at have reported in ACIEE on a combined biosynthesis/chemical synthesis approach to synthesize new ansamitocin analogs.

ACIEE paper

Demethylwyosine biosynthesis

Vahe Bandarian and colleague at the University of Arizona have reported in Biochemistry on the biosynthetic study of demethylwyosine.

Biochemistry paper

Aminoribosyl origin

Steven Van Lanen and co-workers from the University of Kentucky have reported in JACS on the biosynthetic studies of the aminoribosyl functional groups in peptidyl ribosyl natural products.

 

JACS paper

Bactolobin analogs

Jon Clardy and co-workers at Harvard have reported in Organic Letters on the isolation of some compounds by deleting certain genes in B. thailandensis.

OL paper

Allenes from alkynes biosynthetically

Georg Pohnert and co-workers from Friedrich Schiller University have reported in Organic Letters on the biosynthesis of a conjugated allene found in the biosynthetic pathway of moss Dicranum scoparium.

OL paper

Spinosyn A Biosynthesis

Hung-wen Liu and co-workers at UT Austin have reported in Nature on a Diels-Alder reaction being the key step in the biosynthesis of spinosyn A.

Nature paper