Naturalproductman’s Blog

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Archive for the ‘Cancer’ Category

1-Alaninechlamydocin

Posted by naturalproductman on July 15, 2014

Robert Cichewicz and co-workers from the University of Oklahoma have reported in the Journal of Natural Products on the isolation of a tetrapeptide with HDAC inhibitory activity. This compound was isolated from a fungus in Lake Superior.

peptide

JNP paper

Posted in Cancer, Histone deacetylase, Peptides, Protein Targets | Leave a Comment »

Cyanogramide

Posted by naturalproductman on July 15, 2014

Weiming Zhu and co-workers at Ocean University of China have reported in Organic Letters on the isolation of cyanogramide.

cyanogramide

OL paper

Posted in Alkaloids, Cancer, Spirocycles | Leave a Comment »

Stellatolides

Posted by naturalproductman on May 6, 2014

Carmen Cuevas and co-workers from PharmaMar in Spain have reported in JACS on the isolation and syntheses of stellatolides.

stellatolides

JACS paper

Posted in Cancer, Depsipeptides, Peptides, Total Synthesis | Leave a Comment »

VUlgarisin A

Posted by naturalproductman on May 6, 2014

Weidong Pan and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of vulgarisin A.

vulgarisin A

OL paper

Posted in Cancer, Cyclobutanes, Diterpenoids, lung | Leave a Comment »

Peloruside vs. Taxol

Posted by naturalproductman on January 30, 2014

Michel Steinmetz and co-workers from Paul Scherrer Institut in Switzerland have reported in ACIE on a crystal structure of peloruside bound to beta-tubulin. Interestingly, peloruside and taxol bind to beta-tubulin differently.

taxol

ACIE paper

Posted in Cancer, Crystal Structure, Polyketides | Leave a Comment »

Pectenetoxin-2 synthesis

Posted by naturalproductman on December 13, 2013

Kenshu Fujiwara and co-workers from Hokkaido University have reported in ACIE on the synthesis of pectenetoxin-2.

 

ACIE paper

Posted in Cancer, Total Synthesis | Leave a Comment »

Viridicatumtoxin synthesis

Posted by naturalproductman on August 6, 2013

Nicolaou and co-workers at Rice University have reported in ACIE on the synthesis of viridicatumtoxin.

polyketide

ACIE paper

Posted in Cancer, Polyketides | Leave a Comment »

Polycarpathiamines A and B

Posted by naturalproductman on April 18, 2013

Peter Proksch and co-workers from Heinrich-Heine University have reported in OL on the isolation of an interesting looking thiadiazole compound.

thiadiazole

OL paper

Posted in Alkaloids, Cancer, Thiadiazoles | Leave a Comment »

Yaku’amide A synthesis

Posted by naturalproductman on March 22, 2013

Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of some peptides, yaku’amide A.

JACS paper

Posted in Cancer, leukemia, Methodology, Peptides, Total Synthesis | Leave a Comment »

Chlorizidine A

Posted by naturalproductman on February 20, 2013

Chambers Hughes and co-workers at Scripps have reported in Organic Letters on the isolation of chlorizidine A, which had low micromolar LC50 values against some cancer cell lines from NCI. Another interesting point in this paper is the way they assigned the chiral carbon stereocenter as S from an X-ray crystal structure of the molecule, which also incorporated a benzene molecule. They determined the stereocenter using the Flack parameter.

chlorizidine A

OL paper

Flack parameter ref (Acta Cryst)

Posted in Alkaloids, breast, Cancer, melanoma, Stereochemistry | Leave a Comment »

 
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