Naturalproductman’s Blog

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Archive for the ‘Cancer’ Category

Peganumine A

Posted by naturalproductman on July 27, 2014

Hui-Ming Hua and co-workers from Shenyang Pharmaceutical University have reported in Organic Letters on the isolation of peganumine A, which had an IC50 value of 5.8 μM against HL-60 cells.

peganumine A

OL paper

Posted in Alkaloids, Cancer | Leave a Comment »

1-Alaninechlamydocin

Posted by naturalproductman on July 15, 2014

Robert Cichewicz and co-workers from the University of Oklahoma have reported in the Journal of Natural Products on the isolation of a tetrapeptide with HDAC inhibitory activity. This compound was isolated from a fungus in Lake Superior.

peptide

JNP paper

Posted in Cancer, Histone deacetylase, Peptides, Protein Targets | Leave a Comment »

Cyanogramide

Posted by naturalproductman on July 15, 2014

Weiming Zhu and co-workers at Ocean University of China have reported in Organic Letters on the isolation of cyanogramide.

cyanogramide

OL paper

Posted in Alkaloids, Cancer, Spirocycles | Leave a Comment »

Stellatolides

Posted by naturalproductman on May 6, 2014

Carmen Cuevas and co-workers from PharmaMar in Spain have reported in JACS on the isolation and syntheses of stellatolides.

stellatolides

JACS paper

Posted in Cancer, Depsipeptides, Peptides, Total Synthesis | Leave a Comment »

VUlgarisin A

Posted by naturalproductman on May 6, 2014

Weidong Pan and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of vulgarisin A.

vulgarisin A

OL paper

Posted in Cancer, Cyclobutanes, Diterpenoids, lung | Leave a Comment »

Peloruside vs. Taxol

Posted by naturalproductman on January 30, 2014

Michel Steinmetz and co-workers from Paul Scherrer Institut in Switzerland have reported in ACIE on a crystal structure of peloruside bound to beta-tubulin. Interestingly, peloruside and taxol bind to beta-tubulin differently.

taxol

ACIE paper

Posted in Cancer, Crystal Structure, Polyketides | Leave a Comment »

Pectenetoxin-2 synthesis

Posted by naturalproductman on December 13, 2013

Kenshu Fujiwara and co-workers from Hokkaido University have reported in ACIE on the synthesis of pectenetoxin-2.

 

ACIE paper

Posted in Cancer, Total Synthesis | Leave a Comment »

Viridicatumtoxin synthesis

Posted by naturalproductman on August 6, 2013

Nicolaou and co-workers at Rice University have reported in ACIE on the synthesis of viridicatumtoxin.

polyketide

ACIE paper

Posted in Cancer, Polyketides | Leave a Comment »

Polycarpathiamines A and B

Posted by naturalproductman on April 18, 2013

Peter Proksch and co-workers from Heinrich-Heine University have reported in OL on the isolation of an interesting looking thiadiazole compound.

thiadiazole

OL paper

Posted in Alkaloids, Cancer, Thiadiazoles | Leave a Comment »

Yaku’amide A synthesis

Posted by naturalproductman on March 22, 2013

Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of some peptides, yaku’amide A.

JACS paper

Posted in Cancer, leukemia, Methodology, Peptides, Total Synthesis | Leave a Comment »

 
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