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Archive for the ‘Cancer’ Category

Apoptolidins localize in mitochondria

Posted by naturalproductman on November 28, 2014

Gary Sulikowski and co-workers at Vanderbilt University have reported in ACIE on the use of some fluorescent probe versions of apoptolidin natural products and determined that the natural product localizes in the mitochondria of cancer cells.

mitochondria

ACIE paper

Posted in Cancer, Chemical Biology, lung, Polyketides | Leave a Comment »

Plakinamines N and O

Posted by naturalproductman on November 4, 2014

Kirk Gustafson and co-workers from the NCI have reported in JNP on the isolation of plakinamines N and O.
plakinamine

JNP paper

Posted in Alkaloids, Steroids, Cancer, colon | Leave a Comment »

Leiodermatolide synthesis

Posted by naturalproductman on October 28, 2014

Furstner and colleagues have reported in JACS on the synthesis of leiodermatolide.

leiodermatolide

JACS paper

Posted in Cancer, P-glycoprotein, Protein Targets, Total Synthesis | Leave a Comment »

PPARγ is the target of ainsliatrimer A

Posted by naturalproductman on October 4, 2014

Xiaoguang Lei and co-workers from NIBS have reported in ACIE on the target of ainsliatrimer A, which was determined to be PPARγ.

ainsliatrimer A

ACIE paper

Posted in Cancer, Chemical Biology | Leave a Comment »

Hyperuralones A and B

Posted by naturalproductman on September 8, 2014

Gang Xu and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of hyperuralones A and B, which had low micro molar IC50 activity against cancer cells.

cancer

OL paper

Posted in Cancer, Diels-Alder, Isoprenoids, Named Reactions | Leave a Comment »

Sinulariaoid A

Posted by naturalproductman on August 20, 2014

Cui-Xian Zhang and co-workers from Guangzhou University have reported in Tetrahedron on a poly-sulfur lactone compound.

sulfur

Tetrahedron paper

Posted in Apoptosis, Cancer, Lactones, Polythio Compounds | Leave a Comment »

Delta12-prostaglandin J3 synthesis

Posted by naturalproductman on August 18, 2014

Nicolaou and co-workers have reported in ACIE on the synthesis of delta12-prostaglandin J3.

prostaglandin J3

ACIE paper

Posted in Aldol, Cancer, leukemia, Methodology, Polyenes, Prostaglandins, Total Synthesis | Leave a Comment »

Peganumine A

Posted by naturalproductman on July 27, 2014

Hui-Ming Hua and co-workers from Shenyang Pharmaceutical University have reported in Organic Letters on the isolation of peganumine A, which had an IC50 value of 5.8 μM against HL-60 cells.

peganumine A

OL paper

Posted in Alkaloids, Cancer | Leave a Comment »

1-Alaninechlamydocin

Posted by naturalproductman on July 15, 2014

Robert Cichewicz and co-workers from the University of Oklahoma have reported in the Journal of Natural Products on the isolation of a tetrapeptide with HDAC inhibitory activity. This compound was isolated from a fungus in Lake Superior.

peptide

JNP paper

Posted in Cancer, Histone deacetylase, Peptides, Protein Targets | Leave a Comment »

Cyanogramide

Posted by naturalproductman on July 15, 2014

Weiming Zhu and co-workers at Ocean University of China have reported in Organic Letters on the isolation of cyanogramide.

cyanogramide

OL paper

Posted in Alkaloids, Cancer, Spirocycles | Leave a Comment »

 
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