Polycarpathiamines A and B

Peter Proksch and co-workers from Heinrich-Heine University have reported in OL on the isolation of an interesting looking thiadiazole compound.

OL paper

Yaku’amide A synthesis

Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of some peptides, yaku’amide A.

JACS paper

Chlorizidine A

Chambers Hughes and co-workers at Scripps have reported in Organic Letters on the isolation of chlorizidine A, which had low micromolar LC50 values against some cancer cell lines from NCI. Another interesting point in this paper is the way they assigned the chiral carbon stereocenter as S from an X-ray crystal structure of the molecule, which also incorporated a benzene molecule. They determined the stereocenter using the Flack parameter.

OL paper

Flack parameter ref (Acta Cryst)

Siladenoserinols

Sachiko Tsukamoto and co-workers from Kumamoto University have reported in Organic Letters on the isolation of siladenoserinols A-L, which had inhibitory activity against p53 and HDM2 interaction.

OL paper

Radioactive TMZ synthesis

Temozolomide is used to treat brain tumors and its abbreviation, TMZ, is also a TV show name.

OL paper

Tubulexin chemical biology

Herbert Waldmann and co-workers at Max Planck have reported in ACIE on the chemical biology of tubulexins.

ACIE paper

Mollipilins A and B

Teigo Asai and co-workers from Tohoku University have reported in Organic Letters on the isolation of mollipilins A and B, which had moderate cytotoxicity against human colon cancer cells at 1.8 and 3.7 micomolar IC50 values.

OL paper

Xestoquinones

Daniel Nagle and co-workers from the University of Mississippi have reported in JNP on the isolation of xestoquinones.

JNP paper

Inhibition of HIF-2 transcription

Tawnya McKee and co-workers at Frederick National Laboratory for Cancer Research have reported in JNP on some compounds isolated from marine sponges that have HIF-2 transcription inhibition activity.

JNP paper

Abiestetranes A and B

Wei-Dong Zhang and co-workers from have reported in Tetrahedron on the isolation of some spirocyclic tetraterpenes, abiestetranes A and B.

Tetrahedron paper