Chlorizidine A

Chambers Hughes and co-workers at Scripps have reported in Organic Letters on the isolation of chlorizidine A, which had low micromolar LC50 values against some cancer cell lines from NCI. Another interesting point in this paper is the way they assigned the chiral carbon stereocenter as S from an X-ray crystal structure of the molecule, which also incorporated a benzene molecule. They determined the stereocenter using the Flack parameter.

OL paper

Flack parameter ref (Acta Cryst)

Xestoquinones

Daniel Nagle and co-workers from the University of Mississippi have reported in JNP on the isolation of xestoquinones.

JNP paper

Baccharin

Satoshi Endo and co-workers from Gifu Pharmaceutical University have reported in JNP on the isolation of baccharin a 17-beta-hydroxysteroid dehydrogenase inhibitor.

JNP paper

Reversing multi-drug resistance with glycosides

Rogelio Pereda-Miranda and co-workers at Universidad Nacional Autónoma de México have reported in JNP on some glycosides that had reversed the multi-drug resistance in vinblastine resistant human breast cancer cells.

JNP paper

Burkholdac B synthesis

Ganesan and co-workers at the University of Southampton have reported in Organic Letters on a synthesis of burkholdac B, which has an IC50 of 60 pM against MCF7 breast cancer cell lines.

OL paper

Maoecrystal Z synthesis

Sarah Reisman and co-workers have reported in JACS on a total synthesis of maoecrystal Z featuring a samarium mediated radical redutive cyclization of a dialdehyde intermediate.

JACS paper

 

Isolation paper in OL

Premnalatifolin A

Suresh Babu and co-workers at IICT have reported in Tetrahedron Letters on the isolation of a dimeric diterpene dubbed premnalatifolin A from an Indian medicinal plant, Premna latifolia.  This compound had IC₅₀ values of 12.15 and 1.11 μg/mL against HT-29 and MCF-7 cell lines, respectively.

TL paper

Flueggines A and B

Wen-Cai Ye and co-workers at Jinan University have reported in Organic Letters on the isolation of flueggines A and B.  Flueggine B had activity with an IC50 values of 135 ± 5 and 147 ± 3 nM against MCF-7 and MDA-MB-231 cells, respectively.

OL paper

Archazolids E and F

Dirk Mensche and colleagues at Ruprecht-Karls-Universitat Heidelberg in Germany have reported in the Journal of Natural Products on the isolation of archazolids E and F.  Archazolid F had an IC50 of 0.131 nM against MCF7 breast adenocarcinoma cell lines.

JNP paper

Lectin from salmon eggs

Alaa El-Din Ahmed Bekhit and co-workers from the University of Otago have reported in the Journal of Food and Agricultural Chemistry on the isolation of lectin from salmon roe to show inhibitory activity against hepatoma and breast cancer cells.  Lectins are sugar binding proteins.
JAFC paper