Naturalproductman’s Blog

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Archive for the ‘leukemia’ Category

Delta12-prostaglandin J3 synthesis

Posted by naturalproductman on August 18, 2014

Nicolaou and co-workers have reported in ACIE on the synthesis of delta12-prostaglandin J3.

prostaglandin J3

ACIE paper

Posted in Aldol, Cancer, leukemia, Methodology, Polyenes, Prostaglandins, Total Synthesis | Leave a Comment »

Yaku’amide A synthesis

Posted by naturalproductman on March 22, 2013

Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of some peptides, yaku’amide A.

JACS paper

Posted in Cancer, leukemia, Methodology, Peptides, Total Synthesis | Leave a Comment »

Halichoblelides B and C

Posted by naturalproductman on May 2, 2012

Takeshi Yamada and co-workers at Osaka University of Pharmaceutical Sciences have reported in Tetrahedron on the isolation of some cytotoxic natural products, halichoblelides B and C.

anti cancer

TL paper

Posted in Cancer, colon, leukemia, Macrolides | Leave a Comment »

Berkazophilones

Posted by naturalproductman on February 10, 2012

Usually I know a paper from the Stierle lab from the picture of Berkeley Pit lake on their abstract.

caspase-1

JNP paper 1

JNP paper 2

Posted in Cancer, Caspase-1, leukemia, Polyketides, Protein Targets | Leave a Comment »

NP25302 synthesis

Posted by naturalproductman on October 19, 2011

Jeremy Robertson and co-workers at the University of Oxford have reported in Organic Letters on the synthesis of NP25302 taking advantage of a TMSOTf mediated 5-endo-dig cyclization followed by a Curtius rearrangement to form the Csp2-nitrogen bond.

NP25302

OL paper

Posted in Alkaloids, Cancer, Cascade Reactions, Curtius rearrangement, leukemia, Methodology, Named Reactions | Leave a Comment »

Austrocolorone B and austrocolorin B1

Posted by naturalproductman on September 18, 2011

Karen Beattie and co-workers from the University of Melbourne have reported in Tetrahedron Letters on the isolation of anthraquinones (austrocolorone B and austrocolorin B1), and the IC50 values ranged from 10–31 μg/mL towards murine lymphoblast (P388D1) cells.

anthraquinones

TL paper

Posted in Anthracenes, Aromatic, Cancer, leukemia | Leave a Comment »

Chloctanspirones A and B

Posted by naturalproductman on September 18, 2011

Qianqun Gu and co-workers at the Ocean University of China have reported in Tetrahedron on the isolation of some novel polyketides dubbed chloctanspirones A and B.  Chloctanspirone A had an IC50 value of 9.4 micromolar against HL-60 cells.

polyketide

Tetrahedron paper

Posted in Cancer, leukemia, Polyketides | Leave a Comment »

Maoecrystal Z synthesis

Posted by naturalproductman on August 30, 2011

Sarah Reisman and co-workers have reported in JACS on a total synthesis of maoecrystal Z featuring a samarium mediated radical redutive cyclization of a dialdehyde intermediate.

maoecrystal Z

JACS paper

 

Isolation paper in OL

Posted in breast, Cancer, Cascade Reactions, Diterpene, leukemia, Methodology, ovarian, Radical Chemistry, Titanium, Transition Metal | Leave a Comment »

Mixing microbes

Posted by naturalproductman on July 3, 2011

Karina Zuck and co-workers from NCI have reported in JNP on the isolation of N-formyl alkaloids from the co-culture of a fungus and a bacterium.

N-formyl alkaloids

JNP paper

Posted in Alkaloids, Cancer, leukemia | Leave a Comment »

It’s all in one pot!

Posted by naturalproductman on January 26, 2011

Yen-Ho Chu and co-workers at the National Chung Cheng University in Taiwan have published in Organic Letters on a synthesis of luotonin.  This compound has in vitro activity against  murine leukemia P-388 cell line with an IC50 value of 6.3 micromolar.

luotonin

OL paper

Posted in Alkaloids, Cancer, Cascade Reactions, leukemia, Methodology, One pot, Transition Metal, Ytterbium | Leave a Comment »

 
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