Yaku’amide A synthesis

Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of some peptides, yaku’amide A.

JACS paper

Halichoblelides B and C

Takeshi Yamada and co-workers at Osaka University of Pharmaceutical Sciences have reported in Tetrahedron on the isolation of some cytotoxic natural products, halichoblelides B and C.

TL paper

Berkazophilones

Usually I know a paper from the Stierle lab from the picture of Berkeley Pit lake on their abstract.

JNP paper 1

JNP paper 2

NP25302 synthesis

Jeremy Robertson and co-workers at the University of Oxford have reported in Organic Letters on the synthesis of NP25302 taking advantage of a TMSOTf mediated 5-endo-dig cyclization followed by a Curtius rearrangement to form the Csp2-nitrogen bond.

OL paper

Austrocolorone B and austrocolorin B1

Karen Beattie and co-workers from the University of Melbourne have reported in Tetrahedron Letters on the isolation of anthraquinones (austrocolorone B and austrocolorin B1), and the IC50 values ranged from 10–31 μg/mL towards murine lymphoblast (P388D1) cells.

TL paper

Chloctanspirones A and B

Qianqun Gu and co-workers at the Ocean University of China have reported in Tetrahedron on the isolation of some novel polyketides dubbed chloctanspirones A and B.  Chloctanspirone A had an IC50 value of 9.4 micromolar against HL-60 cells.

Tetrahedron paper

Maoecrystal Z synthesis

Sarah Reisman and co-workers have reported in JACS on a total synthesis of maoecrystal Z featuring a samarium mediated radical redutive cyclization of a dialdehyde intermediate.

JACS paper

 

Isolation paper in OL

Mixing microbes

Karina Zuck and co-workers from NCI have reported in JNP on the isolation of N-formyl alkaloids from the co-culture of a fungus and a bacterium.

JNP paper

It’s all in one pot!

Yen-Ho Chu and co-workers at the National Chung Cheng University in Taiwan have published in Organic Letters on a synthesis of luotonin.  This compound has in vitro activity against  murine leukemia P-388 cell line with an IC50 value of 6.3 micromolar.

OL paper

Rossinone Synthesis

Yefeng Tang and co-workers from Tsinghua University have published in Organic Letters on the synthesis of rossinone with the key reaction being an intramolecular vinyl quinone Diels-Alder reaction.  This molecule has an IC50 value of 84 nM against p-388 murine leukemia cell lines.

 

OL paper