Marge Tadesse and co-workers at have reported in Tetrahedron Letters on the isolation of synoxazolidinone C, which had an IC50 value of 30.5 μM against lung fibroblast cells (MRC-5).
Archive for the ‘lung’ Category
Synoxazolidinone C
Posted by naturalproductman on March 14, 2011
Posted in breast, Cancer, lung, melanoma, Oxazoles, oxazolidinone | Leave a Comment »
Divergolides
Posted by naturalproductman on January 12, 2011
Christian Hertweck and co-workersfrom HKI in Germany have published in ACIEE on the isolation of a group of macrolides and divergolide D was the most cytotoxic with IC50 values ranging from 1-2 micromolar against lung cancer (LXFA 629L), pancreatic cancer (PANC-1), renal cancer (RXF 486L), and sarcoma (Saos-2) cancer cell lines.
Posted in Cancer, lung, Macrolides, Polyketides, renal | 1 Comment »
Towards Pectenotoxins
Posted by naturalproductman on August 2, 2010
Georgios Vassilikogiannakis and co-workers at the University of Crete have published in Chemical Communications on a singlet oxygen promoted cascade reaction to obtain the ABC ring system found in pectenotoxin. **Hint: The reaction starts with a double Diels-Alder.
Posted in breast, Cancer, Cascade Reactions, colon, Cycloaddition, Diels-Alder, lung, Methodology, Multi-Component Coupling, Named Reactions, Pericyclic reactions, Polyketides | Leave a Comment »
