Posted by naturalproductman on February 20, 2013
Chambers Hughes and co-workers at Scripps have reported in Organic Letters on the isolation of chlorizidine A, which had low micromolar LC50 values against some cancer cell lines from NCI. Another interesting point in this paper is the way they assigned the chiral carbon stereocenter as S from an X-ray crystal structure of the molecule, which also incorporated a benzene molecule. They determined the stereocenter using the Flack parameter.
Posted in Alkaloids, breast, Cancer, melanoma, Stereochemistry | Leave a Comment »
Posted by naturalproductman on September 15, 2011
Masahisa Nakada and co-workers have reported in ACIEE on a synthesis of ophiobolin where the seven membered ring was accessed via a ring closing metathesis.
Posted in Cancer, Cascade Reactions, melanoma, Metathesis, Methodology, Named Reactions, Reformatsky, Ring forming, Ruthenium, Sesquiterpenoids, Seven-Membered Rings, Transition Metal | Leave a Comment »
Posted by naturalproductman on June 6, 2011
Tawnya McKee and co-workers from NCI have reported in Organic Letters on the isolation of candidaspongiolides that had selective biological activity against melanoma cell lines (LD50 of 19-174 nM).
Posted in Cancer, Macrolides, melanoma, Tetrahydropyran | Leave a Comment »
Posted by naturalproductman on March 14, 2011
Marge Tadesse and co-workers at have reported in Tetrahedron Letters on the isolation of synoxazolidinone C, which had an IC50 value of 30.5 μM against lung fibroblast cells (MRC-5).
Posted in breast, Cancer, lung, melanoma, Oxazoles, oxazolidinone | Leave a Comment »
