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Archive for the ‘melanoma’ Category

Chlorizidine A

Posted by naturalproductman on February 20, 2013

Chambers Hughes and co-workers at Scripps have reported in Organic Letters on the isolation of chlorizidine A, which had low micromolar LC50 values against some cancer cell lines from NCI. Another interesting point in this paper is the way they assigned the chiral carbon stereocenter as S from an X-ray crystal structure of the molecule, which also incorporated a benzene molecule. They determined the stereocenter using the Flack parameter.

chlorizidine A

OL paper

Flack parameter ref (Acta Cryst)

Posted in Alkaloids, breast, Cancer, melanoma, Stereochemistry | Leave a Comment »

Ophiobolin synthesis

Posted by naturalproductman on September 15, 2011

Masahisa Nakada and co-workers have reported in ACIEE on a synthesis of ophiobolin where the seven membered ring was accessed via a ring closing metathesis.

ophiobolin

ACIEE paper

Posted in Cancer, Cascade Reactions, melanoma, Metathesis, Methodology, Named Reactions, Reformatsky, Ring forming, Ruthenium, Sesquiterpenoids, Seven-Membered Rings, Transition Metal | Leave a Comment »

Candidaspongiolides

Posted by naturalproductman on June 6, 2011

Tawnya McKee and co-workers from NCI have reported in Organic Letters on the isolation of candidaspongiolides that had selective biological activity against melanoma cell lines (LD50 of 19-174 nM).

candidaspongiolides

OL paper

Posted in Cancer, Macrolides, melanoma, Tetrahydropyran | Leave a Comment »

Synoxazolidinone C

Posted by naturalproductman on March 14, 2011

Marge Tadesse and co-workers at have reported in Tetrahedron Letters on the isolation of synoxazolidinone C, which had an IC50 value of 30.5 μM against lung fibroblast cells (MRC-5).

synoxazolidinone C

TL paper

Posted in breast, Cancer, lung, melanoma, Oxazoles, oxazolidinone | Leave a Comment »

 
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