Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Carboxylic acids’ Category

Colletoic acid synthesis

Posted by naturalproductman on February 20, 2013

Masahisa Nakada and co-worker from Waseda University have reported in Org Lett on a synthesis of colletoic acid.

synthesis

OL paper

Posted in Carboxylic acids, Spirocycles, Total Synthesis | Leave a Comment »

Psoromic acid inhibits RabGGTase

Posted by naturalproductman on April 23, 2012

Yao-Wen Wu and co-workers at Max Planck have reported in JACS on the inhibition of RabGGTase using psoromic acid.

psoromic acid

JACS paper

Posted in Aromatic, Cancer, Carboxylic acids, Post-Translational Modification, Protein Targets | Leave a Comment »

Diepoxide intermediate

Posted by naturalproductman on April 20, 2012

Hideaki Oikawa and co-workers at Hokkaido University have reported in JACS on a sequential epoxidation of a bis olefin compound to yield a diepoxide that undergoes a ring opening cascade to form two cyclic polyethers (a tetrahydropyran and tetrahydrofuran).

epoxidation

JACS paper

Posted in Biosynthesis, Carboxylic acids, Chemical Biology, Enzymatic, Methodology | Leave a Comment »

Bexarotene and Alzheimer’s

Posted by naturalproductman on February 10, 2012

Many people have probably already heard of this report in Science of an anti-cancer drug, bexarotene, being effective against treating Alzheimer’s disease.

 

Science paper

Posted in Aromatic, Cancer, Carboxylic acids, Proteins, Receptors, Retinoid X receptor (RXR) | 3 Comments »

Arundic acid synthesis

Posted by naturalproductman on January 25, 2012

Rodney Fernandes and co-workers from IIT Bombay have reported in European JOC on the synthesis of arundic acid.

Alzheimer's

European JOC paper

Posted in Alzheimer's, Asymmetric, Carboxylic acids, Cascade Reactions, Diseases, Methodology, Neurodegenerative, Total Synthesis | Leave a Comment »

Trachyspic acid via MCC

Posted by naturalproductman on September 18, 2011

Jeffrey Johnson and co-workers at UNC have reported in Organic Letters on their multi-component coupling reaction to access the carbon backbone of trachyspic acid.

MCC

OL paper

Posted in Carboxylic acids, Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 76 other followers