Naturalproductman’s Blog

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Archive for the ‘Chemical Biology’ Category

Biosynthesis of andrastin A

Posted by naturalproductman on August 3, 2013

Ikuro Abe and co-workers from the University of Tokyo have reported in Tetrahedron on how they reconstituted the biosynthetic pathway for andrastin A in a fungus.

andrastin

Tetrahedron paper

Posted in Biosynthesis, Chemical Biology | Leave a Comment »

Artemisinin semi-synthesis

Posted by naturalproductman on April 25, 2013

Newman and co-workers at Amyris have reported their large scale semi synthesis of artemisinin.

Nature paper

Posted in Chemical Biology | Leave a Comment »

Paxilline biosynthesis

Posted by naturalproductman on January 17, 2013

Hideaki Oikawa and co-workers at Hokkaido University have reported in JACS on a biosynthesis study of paxilline.

paxilline

JACS paper

Posted in Alkaloids, Chemical Biology, Diterpene, Indoles | Leave a Comment »

Not just isolating small molecules anymore…

Posted by naturalproductman on January 17, 2013

Hideaki Oikawa and co-workers from Hokkaido University have reported in Organic Letters on the isolation of an enzyme that was known to produce some natural products. They expressed and purified the enzyme, incubated the enzyme in the presence of substrates:  geranyl diphosphate (GPP) and isopentenyl diphosphate (IPP), and examined the products.

sesterterpene synthase

OL paper

Posted in Chemical Biology, Enzymes, Methodology, Proteins, Sesterterpenes | Leave a Comment »

Aplyronine A target

Posted by naturalproductman on December 11, 2012

Hideo Kigoshi and co-workers from the University of Tsukuba have reported in JACS on a chemical biological approach to find the aplyronine A target.

aplyronine A

JACS paper

 

Posted in Chemical Biology, Macrolides, Methodology, Protein Targets | Leave a Comment »

Tetarimycin A

Posted by naturalproductman on November 27, 2012

Sean Brady and co-workers from Rockefeller University have reported in JACS on the isolation of tetarimycin A, which had a MIC (minimum inhibitory concentration) of 1.5 micrograms/mL against S. aureus 6538P.

antibiotic

JACS paper

Posted in Antibiotics, Chemical Biology, Polyketides | Leave a Comment »

New fuels approach

Posted by naturalproductman on November 9, 2012

Dean Toste and co-workers published in Nature on a way to use bacteria to break down sugars then extracting the broken down products and reacting them together with a palladium catalyst to form a fuel source.

 

Nature paper

Posted in Chemical Biology, Environmental, Methodology | Leave a Comment »

Foamy beer gene

Posted by naturalproductman on November 8, 2012

Tomas Villa and co-workers from the University of Santiago de Compostela have published in JAFC on the isolation of the foaming gene found in yeast to make foamy beer.

foamy

JAFC paper

Posted in Chemical Biology | Leave a Comment »

Enantioselective ketone reduction with enzymes

Posted by naturalproductman on November 8, 2012

Manfred Reetz and co-workers from Max-Planck have reported in JACS on a directed evolution study to determine a difference in enantioselectivity of a reduction of a ketone.

reduction
JACS paper

Posted in Asymmetric, Chemical Biology, Methodology | Leave a Comment »

Tubulexin chemical biology

Posted by naturalproductman on October 25, 2012

Herbert Waldmann and co-workers at Max Planck have reported in ACIE on the chemical biology of tubulexins.

tubulexins

ACIE paper

Posted in Cancer, Chemical Biology, Methodology, Protein Targets, Unnatural Products | Leave a Comment »

 
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