Naturalproductman’s Blog

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Archive for the ‘Chemical Biology’ Category

Combining chemical and enzymatic synthesis

Posted by naturalproductman on November 29, 2014

Kevin Reynolds and co-workers from Portland State University have reported in JOC on the synthesis of premarineosin analogs using a chemo-enzymatic approach.

marineosin

JOC paper

Posted in Alkaloids, Chemical Biology, Enzymatic, Methodology, Total Synthesis, Unnatural Products | 1 Comment »

Apoptolidins localize in mitochondria

Posted by naturalproductman on November 28, 2014

Gary Sulikowski and co-workers at Vanderbilt University have reported in ACIE on the use of some fluorescent probe versions of apoptolidin natural products and determined that the natural product localizes in the mitochondria of cancer cells.

mitochondria

ACIE paper

Posted in Cancer, Chemical Biology, lung, Polyketides | Leave a Comment »

Monodihydrosterculin

Posted by naturalproductman on November 27, 2014

Ehud Landau and co-workers at the University of Zurich have reported in ACIE on the use of a cyclopropane-containing lipid to crystallize membrane proteins.
MDS

ACIE paper

Posted in Chemical Biology, Lipids, New Setups, Unnatural Products | Leave a Comment »

Imaging bacterial infections

Posted by naturalproductman on November 10, 2014

Niren Murthy and co-workers from UC Berkeley have reported in ACIE on a way to image bacterial infections.

bacteria

ACIE paper

Posted in Chemical Biology, Imaging, Methodology | Leave a Comment »

Spinosyn A, chemoenzymatically

Posted by naturalproductman on October 11, 2014

Hung-Wen Liu and co-workers from UT Austin have reported in ACIE on the chemoenzymatic synthesis of spinosyn A.

spinosyn A

 

ACIE paper

Posted in Chemical Biology, Chemoenzymatic | Leave a Comment »

PPARγ is the target of ainsliatrimer A

Posted by naturalproductman on October 4, 2014

Xiaoguang Lei and co-workers from NIBS have reported in ACIE on the target of ainsliatrimer A, which was determined to be PPARγ.

ainsliatrimer A

ACIE paper

Posted in Cancer, Chemical Biology | Leave a Comment »

Cholesterol analog to probe SHH protein

Posted by naturalproductman on August 20, 2014

Edward Tate and co-workers from Imperial College in London have reported in Chemical Science on a cholesterol analog that allowed them to probe the sonic hedgehog protein, a peptide that undergoes post-translational modification with cholesterol.

cholesterol

Chemical Science paper

Posted in Chemical Biology, Unnatural Products | Leave a Comment »

Merochlorins A and B syntheses, enzymatically

Posted by naturalproductman on August 18, 2014

Bradley Moore and Phil Baran’s groups teamed up to synthesize merochlorin A and B.

Merochlorin

ACIE paper

Posted in Biosynthesis, Chemical Biology, Enzymatic, Polyketides, Total Synthesis | Leave a Comment »

Lomaiviticins and DNA damage

Posted by naturalproductman on July 16, 2014

Seth Herzon and co-workers have reported in ACIE on the DNA damage activity of lomaiviticins.

lomaiviticins

ACIE paper

Posted in Aromatic, Chemical Biology | Leave a Comment »

Polyketide-peptide hybrid

Posted by naturalproductman on June 28, 2014

Liangcheng Du and co-workers at University of Nebraska-Lincoln have reported in ACIE on a polyketide synthase–nonribosomal peptide synthetase that made a hybrid polyketide-peptide compound.

polyketide

ACIE paper

Posted in Chemical Biology, Hybrids, Peptides, Polyketides | Leave a Comment »

 
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