Daphnane diterpenes

Matthias Hamburger and co-workers from the University of Basel in Switzerland have reported in JNP on the anti-HIV activities of some daphnane derived natural products.

JNP paper

Stelleralides

Kuo-Hsiung Lee and co-workers at the University of North Carolina have reported in Organic Letters on the isolation of a very potent anti-HIV compound stelleralide A, which had an EC90 of 0.4 nM.

OL paper

Trigoxyphins A-G

Jian-Min Yue and co-workers from the Chinese Academy of Sciences have published in the Journal of Natural Products on the isolation of diterpenes dubbed trigoxyphins.  Trigoxyphin A had an IC50 value against HL60 human leukemia cells of 0.27 micromolar.

JNP paper

Trigochinins

Jian-Min Yue and co-workers at the Chinese Academy of Sciences have recently published on the isolation of trigochinin C, which had an IC50 value of 1.95 micromolar against MET tyrosine kinase activity.

OL paper

Rediocide A

Sheo Singh at Merck Laboratories isolated a compound that kills fleas at the 1 ppm level activity. This seven membered containing polyclic daphnane was isolated and published in JACS.

JACS link

Kirkinine – a Neurotophic Active Molecule

Basically some people in Ghent found this molecule called kirkinine,and they found that at the nM levels, it promotes neuronal survival.  The structure is unique in that it has a seven membered ring.

JNP article