Mbandakamines A and B

Gerhard Bringmann and co-workers at the University of Wurzberg have reported in OL on the isolation of anti-malarial mbandakamines A and B.

OL paper

Myriberine A

Xiao-Jiang Hao and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of myriberine A, a pentacyclic alkaloid.

OL paper

Densanins A and B

Jung-Rae Rho and co-workers at Kunsan University in Korea have reported in Organic Letters on the isolation of densanins A and B, some pyrrole containing alkaloids, with  IC₅₀ values of 1.05 and 2.14 μM against lipopolysaccharide-induced nitric oxide production in BV2 microglial cells.

 

OL paper

HIV-1 reverse transcriptase structure with catechol diether

Karen Anderson and co-workers at Yale have reported in JACS on a crystal structures of HIV-1 reverse transcriptase with catechol diether drugs.

JACS paper

Anti-protozoal cristaxenicin A

Yoichi Nakao and co-workers from Waseda University have reported in JOC on the isolation of cristaxenicin A, which had activities against Leishmania amazonensis (IC₅₀ value of 0.088 μM) and Trypanosoma congolense (IC₅₀ value of 0.25 μM).

JOC paper

Amphilectene synthesis

Ryan Shenvi and colleague at Scripps have reported in JACS on the synthesis of amphilectene, an antimalarial compound.

JACS paper

Gracilioether H has anti-malarial activity

Angela Zampella and co-workers have reported in Tetrahedron on the isolation of gracilioethers.  Gracilioether H had anti-malarial activity.

Tetrahedron paper

Type 2 diabetes therapeutic?

Here’s a study by Zhong-Yin Zhang and co-workers at Indiana University on a PTP-MEG2 inhibitor.

JACS paper

Epicoccin G, 8,8ʹ-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E and Haematocin – total synthesis

Nicolaou and co-workers have reported in JACS on the syntheses and anti-malarial activities of some polythio compounds.

JACS paper

Artemisinin synthesis

Silas Cook and colleague at Indiana University have reported in JACS on a synthesis of artemisinin using a molybdenum promoted in situ formation of singlet oxygen to form the endoperoxide.

JACS paper