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Archive for the ‘Diseases’ Category

Cardamom peroxide synthesis

Posted by naturalproductman on March 27, 2014

Thomas Maimone and co-worker from UC Berkeley have reported in JACS on a 4-step synthesis of cardamom peroxide from myrtenal.

 

 

JACS paper

Posted in Diseases, Malaria, Peroxides, Total Synthesis | Leave a Comment »

Sweriledugenin A

Posted by naturalproductman on December 30, 2013

Ji-Jun Chen and co-workers at the Kunming Institute of Botany have reported in Org Lett on the isolation of sweriledugenin A.

lactone

OL paper

Posted in Anti-viral, Diseases, Lactones, Mass Spectrometry | Leave a Comment »

MA026 synthesis

Posted by naturalproductman on December 9, 2013

Fumio Sugawara and co-workers at the Tokyo University of Science have reported in JACS on the synthesis of MA026 and its anti-hepatitis C virus activity.

HCV

JACS paper

Posted in Anti-viral, Diseases, Hepatitis C, Peptides, Total Synthesis | Leave a Comment »

Samroiyotmycins A and B

Posted by naturalproductman on August 3, 2013

Pattama Pittayakhajonwut and co-workers from BIOTEC in Thailand have reported in Tetrahedron on the isolation of samroiyotmycins A and B, anti-malarial macrolides from bacteria.

ssamroiyotmycin

Tetrahedron paper

Posted in Diseases, Macrolides, Malaria | Leave a Comment »

Mbandakamines A and B

Posted by naturalproductman on May 16, 2013

Gerhard Bringmann and co-workers at the University of Wurzberg have reported in OL on the isolation of anti-malarial mbandakamines A and B.
mbandakamines

OL paper

Posted in Alkaloids, Diseases, Malaria | Leave a Comment »

Myriberine A

Posted by naturalproductman on January 17, 2013

Xiao-Jiang Hao and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of myriberine A, a pentacyclic alkaloid.

alkaloid

OL paper

Posted in Alkaloids, Diseases, Hepatitis C | Leave a Comment »

Densanins A and B

Posted by naturalproductman on December 5, 2012

Jung-Rae Rho and co-workers at Kunsan University in Korea have reported in Organic Letters on the isolation of densanins A and B, some pyrrole containing alkaloids, with  IC50 values of 1.05 and 2.14 μM against lipopolysaccharide-induced nitric oxide production in BV2 microglial cells.

 

densanins

OL paper

Posted in Alkaloids, Diseases | Leave a Comment »

HIV-1 reverse transcriptase structure with catechol diether

Posted by naturalproductman on November 19, 2012

Karen Anderson and co-workers at Yale have reported in JACS on a crystal structures of HIV-1 reverse transcriptase with catechol diether drugs.

HIV

JACS paper

Posted in Aromatic, Diseases, Enzymes, HIV, Proteins | Leave a Comment »

Anti-protozoal cristaxenicin A

Posted by naturalproductman on November 19, 2012

Yoichi Nakao and co-workers from Waseda University have reported in JOC on the isolation of cristaxenicin A, which had activities against Leishmania amazonensis (IC50 value of 0.088 μM) and Trypanosoma congolense (IC50 value of 0.25 μM).

crystaxenicin A

JOC paper

Posted in Anti-protozoal, Diseases, Trophy Targets | Leave a Comment »

Amphilectene synthesis

Posted by naturalproductman on November 16, 2012

Ryan Shenvi and colleague at Scripps have reported in JACS on the synthesis of amphilectene, an antimalarial compound.

amphilectene

JACS paper

Posted in Diseases, Malaria, Terpenoids, Total Synthesis | Leave a Comment »

 
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