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Archive for the ‘Alzheimer’s’ Category

Arundic acid synthesis

Posted by naturalproductman on January 25, 2012

Rodney Fernandes and co-workers from IIT Bombay have reported in European JOC on the synthesis of arundic acid.

Alzheimer's

European JOC paper

Posted in Alzheimer's, Asymmetric, Carboxylic acids, Cascade Reactions, Diseases, Methodology, Neurodegenerative, Total Synthesis | Leave a Comment »

Jiadifenone

Posted by naturalproductman on January 17, 2012

Miwa Kubo and co-workers at Tokushima Bunri University have reported in Tetrahedron Letters on some norsesquiterpenoids from Illicium jiadifengpi possessing neurotrophic activity.  This Illicium species is the same name that merrilactone came from (Illicium merrillianum)

neurotrophic

TL paper

Posted in Alzheimer's, Diseases, Neurodegenerative, Norsesquiterpenes | Leave a Comment »

Theaflavins for Alzheimer’s and Parkinson’s

Posted by naturalproductman on November 19, 2011

Jan Bieschke and co-workers at Washington University in St. Louis have reported in Biochemistry on the inhibition of theaflavins as inhibitors of amyloid-beta and alpha-synuclein fibrillogenesis.

theaflavins

Biochemistry paper

Posted in Alzheimer's, Aromatic, Diseases, Flavins, Parkinson's, Polyphenolic | Leave a Comment »

Dragmacidin D through C-H activation

Posted by naturalproductman on November 16, 2011

Kenichiro Itami and co-workers from Nagoya University have reported in JACS on a synthesis of dragmacidin D using C-H activation as the strategy.
dragmacidin

JACS paper

Posted in Alkaloids, Alzheimer's, C-H activation, cross coupling, Diseases, Methodology, Palladium, Total Synthesis, Transition Metal | Leave a Comment »

Proteomes vs. Disease

Posted by naturalproductman on October 30, 2011

Theo Luider and colleagues at Erasmus Medical Center in the Netherlands have reported in the Journal of Proteome Research on the higher concentration of PZP (Pregnancy Zone Protein) in presymptomatic Alzheimer’s disease group of women.

AD

Journal of Proteome Research paper

Posted in Alzheimer's, Diseases, Peptides, Proteomics | Leave a Comment »

Sebestenoids

Posted by naturalproductman on May 16, 2011

Philip Williams and co-workers at the University of Hawaii have reported in Phytochemistry on the isolation of sebestenoids.  Sebestenoid D had an IC50 value of 65 micromolar against BACE1 aspartic protease in the presence of detergent.

sebestenoid

Phytochemistry paper

Posted in Alzheimer's, Aromatic, Diseases | Leave a Comment »

A protein responsible for enhancing memory?

Posted by naturalproductman on March 5, 2011

Yadin Dudai and colleagues at the Weizmann Institute have reported in Science on a protein that is responsible for improving long term memory (PKMzeta).

 

Science paper

Posted in Alzheimer's, Diseases, Proteins | Leave a Comment »

Nobiletin Studies

Posted by naturalproductman on January 24, 2011

Toshiyuki Kan and co-workers at the University of Shizuoka and Global COE program have reported in Chem Comm on a total synthesis of nobiletin where they incorporated a 11C isotope to visualize the compound through PET (positron emission tomography) in order to see where it goes in the rat brain.  Nobiletin was found to enhance PKA/ERK/CREB signalling in rat hippocampal neurons.

nobiletin

Chem Comm paper

Posted in Alzheimer's, Aromatic, Diseases, Methodology, Total Synthesis | Leave a Comment »

Some New Galbulimima Alkaloids

Posted by naturalproductman on December 13, 2010

When I saw the term “galubulimima” I knew that the corresponding author was related to Lewis Mander – he and co-workers have recently isolated a new set of galubulimima alkaloids.

galbulimima

 

TL paper

Posted in Alkaloids, Alzheimer's, Diseases | Leave a Comment »

Eutypoids B-E

Posted by naturalproductman on December 6, 2010

Johannes Imhoff and co-workers at Leibniz-Institute of Marine Sciences have published in the Journal of Natural Products on the isolation of eutypoids B-E from the Penicillium sp. strain KF620 i.  Eutypoid B had an IC50 of 0.78 micromolar against glycogen synthase kinase-3β (GSK-3β), which is a target for treating type 2 diabetes and Alzheimer’s disease.

eutypoids

JNP paper

Posted in Alzheimer's, Aromatic, Butenolides, Diabetes Type 2, Diseases, glycogen synthase kinase-3β (GSK-3β), Protein Targets | Leave a Comment »

 
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