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Archive for the ‘Diabetes Type 2’ Category

Type 2 diabetes therapeutic?

Posted by naturalproductman on October 23, 2012

Here’s a study by Zhong-Yin Zhang and co-workers at Indiana University on a PTP-MEG2 inhibitor.

diabetes 2

JACS paper

Posted in Chemical Biology, Diabetes Type 2, Diseases, Methodology, Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Proteins | Leave a Comment »

Cytopiloyne synthesis

Posted by naturalproductman on June 19, 2011

Jinq-Chyi Lee and co-workers at the Institute of Biotechnology and Pharmaceutical research in Taiwan have reported in Chemistry a European Journal on a polyne natural product that has anti-diabetic activity.

glycosylation

Chemistry a European Journal paper

Posted in Diabetes Type 2, Diseases, Glycosides, Polyynes | Leave a Comment »

Tatanans

Posted by naturalproductman on March 3, 2011

Tatanans were isolated from the rhizomes of Acorus tatarinowii Schott by De-Quan Yu and co-workers at the Chinese Academy of Medical Sciences and Peking Union Medical College.  These compounds were found to have antihyperglycemic activity with EC1.5 values ranging from 0.16−1.85 μM.

tatanans

 

JOC paper

Posted in Aromatic, Diabetes Type 2, Diseases, glucokinase, Protein Targets | Leave a Comment »

Pallensin from Davana

Posted by naturalproductman on February 14, 2011

Anjali Ruikar and co-workers have reported the isolation of some compounds dubbed pallensin from the plant Artemisia pallens WALLS ex DC.  The methanol extract of the plant was found to have anti-diabetic activities.

pallensin

HCA paper

Posted in Diabetes Type 2, Diseases, Eudesmanolides | Leave a Comment »

Eutypoids B-E

Posted by naturalproductman on December 6, 2010

Johannes Imhoff and co-workers at Leibniz-Institute of Marine Sciences have published in the Journal of Natural Products on the isolation of eutypoids B-E from the Penicillium sp. strain KF620 i.  Eutypoid B had an IC50 of 0.78 micromolar against glycogen synthase kinase-3β (GSK-3β), which is a target for treating type 2 diabetes and Alzheimer’s disease.

eutypoids

JNP paper

Posted in Alzheimer's, Aromatic, Butenolides, Diabetes Type 2, Diseases, glycogen synthase kinase-3β (GSK-3β), Protein Targets | Leave a Comment »

Duboscic acid

Posted by naturalproductman on November 22, 2010

Pascal Wafo and co-workers from France have published in Organic Letters on the isolation of duboscic acid.  It had alpha-glucosidase inhibition activity with with an IC50 value of 100 ± 8.1 μM.  So you might wonder why alpha-glucosidase inhibition is important – alpha-glucosidase is an enzyme that hydrolyzes disaccharides into monosaccharides so the inhibition of this enzyme should slow down the absorption of glucose in people, which is especially important in diabetic patients.

triterpenoid

 

OL paper

Posted in Diabetes Type 2, Diseases, Seven-Membered Rings, Triterpenoids | Leave a Comment »

Grecocycline B

Posted by naturalproductman on March 20, 2010

Thomas Paululat and co-workers at the University of Siegen in Germany have recently reported on the isolation of grecocycline B from Streptomyces sp. Acta 1362.  The new polycyclic compound had an IC50 of 0.52 micromolar against tyrosine phosphatase B1.  Interestingly, protein tyrosine phosphatase PTP1B is a target for the treatment of obesity, type 2 diabetes and cancer.
grecocycline B

European JOC paper

Posted in Angucyclines, Aromatic, Diabetes Type 2, Diseases, Obesity, Polycyclic, SAR studies | Leave a Comment »

 
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