Naturalproductman’s Blog

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Archive for the ‘HIV’ Category

Logeracemin A

Posted by naturalproductman on May 21, 2014

Jian-Min Yue and co-workers from the Chinese Academy of Sciences have reported in JACS on the isolation of logeracemin A.

logeracemin A

JACS paper

Posted in Alkaloids, C2-Symmetric, Diseases, HIV | Leave a Comment »

HIV-1 reverse transcriptase structure with catechol diether

Posted by naturalproductman on November 19, 2012

Karen Anderson and co-workers at Yale have reported in JACS on a crystal structures of HIV-1 reverse transcriptase with catechol diether drugs.

HIV

JACS paper

Posted in Aromatic, Diseases, Enzymes, HIV, Proteins | Leave a Comment »

Aetheramides A and B

Posted by naturalproductman on May 29, 2012

Rolf Mueller and co-workers at Universität des Saarlandes have reported in Organic Letters on some anti-HIV depsipeptides with 15 nM IC50 values.

depsipeptides

OL paper

Posted in Depsipeptides, Diseases, HIV | Leave a Comment »

Oxyingenol synthesis

Posted by naturalproductman on April 17, 2012

Hideo Kigoshi and co-workers from the University of Tsukuba have reported in ACIE on the synthesis of oxyingenol.

oxyingenol

ACIE paper

Posted in Diseases, Diterpenoids, HIV, Metathesis, Methodology, Ruthenium, Sigmatropic Rearrangements, Total Synthesis, Transition Metal | Leave a Comment »

Anti-HIV schilancitrilactone

Posted by naturalproductman on February 20, 2012

Han-Dong Sun and co-workers from the Kunming Institute of Botany have reported in Organic Letters on the isolation of schilancitrilactones A-C.

schilancitrilactones A-C

OL paper

Posted in Diseases, HIV, Lactones, Nortriterpenoids, Seven-Membered Rings | Leave a Comment »

Daphnane diterpenes

Posted by naturalproductman on January 21, 2012

Matthias Hamburger and co-workers from the University of Basel in Switzerland have reported in JNP on the anti-HIV activities of some daphnane derived natural products.

HIV

JNP paper

Posted in Daphnane, Diseases, Diterpene, HIV | Leave a Comment »

Video games and protein structures

Posted by naturalproductman on September 20, 2011

David Baker and co-workers at the University of Washington have reported in Nature Structral and Molecular Biology on the structure of an HIV protease enzyme.  Their approach involved the use of a video game called Foldit.

Nature Structural and Molecular Biology

Posted in Computational, Diseases, Enzymes, HIV, M-PMV (Mason-Pfizer monkey virus) retroviral protease, Molecular modeling, Protein Targets, Proteins | Leave a Comment »

EFdA synthesis

Posted by naturalproductman on September 4, 2011

Shigefumi Kuwahara and co-workers from Tohoku University have reported in Organic Letters on their synthesis of an anti-HIV compound, 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA).

HIV

OL paper

Posted in Diseases, HIV, Methodology, Nucleic acids, Total Synthesis | Leave a Comment »

Salviadione synthesis

Posted by naturalproductman on June 9, 2011

Bjorn Soderberg and co-workers at West Virginia University have reported in Tetrahedron on a synthesis of salviadione with the key reaction being a palladium mediated C-N bond formation.

salviadione

Tetrahedron paper

Posted in Alkaloids, Aromatic, Cascade Reactions, Diseases, HIV, Methodology, Palladium, Transition Metal | Leave a Comment »

Stelleralides

Posted by naturalproductman on May 12, 2011

Kuo-Hsiung Lee and co-workers at the University of North Carolina have reported in Organic Letters on the isolation of a very potent anti-HIV compound stelleralide A, which had an EC90 of 0.4 nM.

sterlleralide

OL paper

Posted in Daphnane, Diseases, Diterpene, HIV, Trophy Targets | Leave a Comment »

 
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