Naturalproductman’s Blog

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Archive for the ‘Neurodegenerative’ Category

Merrilactone synthesis

Posted by naturalproductman on May 5, 2012

Hongbin Zhai and co-workers at the Chinese Academy of Sciences have published in ACIE on the synthesis of merrilactone where they used a Pauson-Khand reaction as one of the key steps.

Pauson-Khand

ACIE paper

Posted in Cascade Reactions, Johnson Claisen rearrangement, Methodology, Named Reactions, Neurodegenerative, Pauson-Khand, Triterpenoids | Leave a Comment »

Arundic acid synthesis

Posted by naturalproductman on January 25, 2012

Rodney Fernandes and co-workers from IIT Bombay have reported in European JOC on the synthesis of arundic acid.

Alzheimer's

European JOC paper

Posted in Alzheimer's, Asymmetric, Carboxylic acids, Cascade Reactions, Diseases, Methodology, Neurodegenerative, Total Synthesis | Leave a Comment »

Jiadifenone

Posted by naturalproductman on January 17, 2012

Miwa Kubo and co-workers at Tokushima Bunri University have reported in Tetrahedron Letters on some norsesquiterpenoids from Illicium jiadifengpi possessing neurotrophic activity.  This Illicium species is the same name that merrilactone came from (Illicium merrillianum)

neurotrophic

TL paper

Posted in Alzheimer's, Diseases, Neurodegenerative, Norsesquiterpenes | Leave a Comment »

Ganglioside LLG-3 Synthesis

Posted by naturalproductman on February 8, 2011

Makoto Kiso and co-workers at Gifu University have published in ACIEE on a total synthesis of ganglioside LLG-3.

glucoside

ACIEE paper

Posted in Carbohydrates, Diseases, Methodology, Neurodegenerative, Total Synthesis | Leave a Comment »

Synthesis of Merrilactone

Posted by naturalproductman on October 22, 2010

Michael Greaney and co-workers at the University of Edinburgh have published on the racemic synthesis of merrilactone.  One of the highlights is a radical cascade that involves the use of a titanium reagent on an epoxy alkyne substrate, which undergoes an epoxide opening and a 5-exo dig cyclization.

5 exo

ACIEE paper

Posted in Cascade Reactions, Diseases, Methodology, Neurodegenerative, Radical Chemistry, Titanium, Transition Metal | 1 Comment »

Hoiamides

Posted by naturalproductman on August 6, 2010

William Gerwick and co-workers have published on their studies of hoiamides, which may be a target for voltage gate sodium channels (VGSC).  This channel is a target for the treatment of neurodegenerative disorders – there are neurotoxin sites (at least seven) on VGSCs that are targeted by drugs.

hoiamides


JNP paper

Posted in Macrocycles, Neurodegenerative, Polyketides, Polythio Compounds, SAR studies | Leave a Comment »

 
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