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Archive for the ‘Indoles’ Category

Indole alkaloid synthesis

Posted by naturalproductman on July 15, 2014

Corey Stephenson and colleague at the University of Michigan have reported in JACS on the synthesis of pseudotabersonine. A mental roadblock for me was when I was looking at the paper, I was trying to find the structure of catalyst 5, which was the iridium catalyst used for a ring opening reaction, but just found the number 5 in the scheme. Within the text of the paper however it says Ir(dF(CF3)ppy)2(dtbbpy)PF6, which was cited with a Sigma Aldrich catalog number.

 

photoredox

JACS paper

Posted in Alkaloids, Indoles, Iridium, Light Mediated, Methodology, Transition Metal | Leave a Comment »

Dimerization, electrochemically

Posted by naturalproductman on April 18, 2014

Phil Baran and co-workers reported in JACS on a synthesis of dixiamycin via electrochemical dimerization. I usually think of Kevin Moeller from Washington University in St. Louis when I see electrochemical reactions.

JACS paper

Posted in Dimer, Electrochemical, Indoles, Methodology, Total Synthesis | Leave a Comment »

Indole alkaloids

Posted by naturalproductman on December 17, 2013

Jieping Zhu and co-workers haver reported in JACS on the syntheses of some indole alkaloids.

indole

 

 

JACS paper

Posted in Alkaloids, Indoles, Methodology, Total Synthesis | Leave a Comment »

Chimonanthine synthesis

Posted by naturalproductman on October 11, 2013

Dawei Ma and co-workers at SIOC have reported in ACIE on the synthesis of

indole

ACIE paper

Posted in Indoles, Total Synthesis | Leave a Comment »

Voattingine and Tabertinggine

Posted by naturalproductman on August 30, 2013

Toh-Seok Kham and co-workers at Malaya University have reported in Org Lett on some indole alkaloids.

indole

OL paper

Posted in Alkaloids, Indoles | Leave a Comment »

Actinophyllic acid synthesis

Posted by naturalproductman on August 26, 2013

Stephen Martin and co-workers have reported in JACS on a racemic synthesis of actinophyllic acid.

actinophyllic acid

JACS paper

Posted in Alkaloids, Indoles, Total Synthesis | Leave a Comment »

Paxilline biosynthesis

Posted by naturalproductman on January 17, 2013

Hideaki Oikawa and co-workers at Hokkaido University have reported in JACS on a biosynthesis study of paxilline.

paxilline

JACS paper

Posted in Alkaloids, Chemical Biology, Diterpene, Indoles | Leave a Comment »

Original isolators publish synthesis

Posted by naturalproductman on January 17, 2013

Xiao-Jiang Hao and co-workers from Chinese Academy of Sciences have reported in Org Lett on the synthesis of trigonoliimine A.

trigonoliimine A

OL paper

Posted in Alkaloids, Indoles, Methodology, Total Synthesis | Leave a Comment »

Paspalinine synthesis

Posted by naturalproductman on November 16, 2012

Shigefumi Kuwahara and co-workers from Tohoku University have reported in ACIE on the synthesis of paspalinine.

paspalinine
ACIE paper

Posted in Alkaloids, Cascade Reactions, Indoles, Methodology, Palladium, Total Synthesis, Transition Metal | Leave a Comment »

Flinderole A synthesis

Posted by naturalproductman on April 11, 2012

Jeremy May and colleague at the University of Houston have reported in JACS on a synthesis of flinderole A.

flinderole

JACS paper

Posted in Alkaloids, Diseases, Indoles, Malaria, Methodology, Total Synthesis | Leave a Comment »

 
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