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Archive for the ‘Macrolides’ Category

Tiacumicin B (Lipiarmycin A3/Fidaxomicin) aglycone synthesis

Posted by naturalproductman on December 15, 2014

Karl Heinz-Altmann and co-workers at ETH Zurich have reported in ACIE on the synthesis of fidaxomicin aglycone.

fidaxomicin

ACIE paper

Posted in Macrolides, Polyenes, Polyketides, Total Synthesis | Leave a Comment »

Cochliomycin synthesis via NHK

Posted by naturalproductman on November 29, 2014

Martin Banwell and co-workers at the Australian National University have reported in JOC on the synthesis of cochliomycins A and B.

cochliomycins

JOC paper

Posted in cross coupling, Macrolides, Metathesis, Methodology, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

Mandelalide A synthesis

Posted by naturalproductman on May 22, 2014

Tao Ye and co-workers at Hong Kong Polytechnic University have reported in ACIE on the synthesis of mandelalide.

mandelalide

ACIE paper

Posted in Macrolides, Total Synthesis | Leave a Comment »

Macrolactonization towards neopeltolide

Posted by naturalproductman on May 13, 2014

Mingji Dai and co-workers from Purdue have reported in ACIE on alkoxycarbonylative macrocyclization.

Pd

ACIE paper

Posted in Macrolides, Methodology, Palladium, Transition Metal | Leave a Comment »

Mandelalide A synthesis

Posted by naturalproductman on March 14, 2014

Furstner and co-workers published in ACIE on the synthesis of mandelalide A, a macrolide found in South Africa. I wonder if this compound was named after Nelson Mandela.

mandelalide

ACIE paper

Posted in Macrolides, Methodology, Total Synthesis | 2 Comments »

Leiodermatolide synthesis

Posted by naturalproductman on February 2, 2014

Ian Paterson and co-workers at the University of Cambridge have reported in ACIE on the synthesis of leiodermatolide.

macrolide

ACIE paper

Posted in Macrolides, Methodology, Total Synthesis | Leave a Comment »

Samroiyotmycins A and B

Posted by naturalproductman on August 3, 2013

Pattama Pittayakhajonwut and co-workers from BIOTEC in Thailand have reported in Tetrahedron on the isolation of samroiyotmycins A and B, anti-malarial macrolides from bacteria.

ssamroiyotmycin

Tetrahedron paper

Posted in Diseases, Macrolides, Malaria | Leave a Comment »

Amphidinolides C and F syntheses

Posted by naturalproductman on July 11, 2013

Rich Carter and colleague have reported in JACS on a synthesis of amphidinolides C and F.

amphidinolide

JACS paper

Posted in C2-Symmetric, Macrolides, Methodology, Total Synthesis | Leave a Comment »

Dictyostatin synthesis

Posted by naturalproductman on May 17, 2013

James Leighton and co-workers have reported in ACIE on the synthesis of dictyostatin.

dictyostatin

ACIE paper

Posted in Macrolides, Methodology, Total Synthesis | Leave a Comment »

Rhizopodin synthesis

Posted by naturalproductman on May 8, 2013

Ian Paterson and co-workers from the University of Cambridge have reported in ACIE on the synthesis of rhizopodin.

rhizopodin

ACIE paper

Posted in Macrolides, Methodology, Oxazoles, Total Synthesis | Leave a Comment »

 
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