Naturalproductman’s Blog

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Archive for the ‘Mass Spectrometry’ Category

Sweriledugenin A

Posted by naturalproductman on December 30, 2013

Ji-Jun Chen and co-workers at the Kunming Institute of Botany have reported in Org Lett on the isolation of sweriledugenin A.

lactone

OL paper

Posted in Anti-viral, Diseases, Lactones, Mass Spectrometry | Leave a Comment »

Asymmetric epoxidation

Posted by naturalproductman on April 19, 2013

Benjamin List and co-workers have reported in JACS on their studies of cinchona alkaloid catalyzed asymmetric epoxidation of activated olefins.

cinchona

JACS paper

Posted in Asymmetric, Computational, DFT, ESI, Mass Spectrometry, Mechanistic, Methodology, Organocatalytic | Leave a Comment »

Metabolomics

Posted by naturalproductman on December 19, 2012

At some point I’m going to need to review principal component analysis to truly understand this metabolomics study that identified a small molecule phermone.

ACIE paper

Posted in Computational, Mass Spectrometry, Metabolomics | Leave a Comment »

Determination of stereochemistry on a small scale

Posted by naturalproductman on December 5, 2012

Scptt Rychnovsky and co-workers have reported in JACS on a clever way to determine the stereochemical configuration of a primary amine by using mass spectrometry.  This may be useful when you only have a small amount of material.

chirality

JACS paper

Posted in Asymmetric, Kinetic resolution, Mass Spectrometry, Methodology | Leave a Comment »

Named reaction refresher

Posted by naturalproductman on January 19, 2012

The Criegee rearrangement converts a tertiary alcohol into an alcohol and a ketone by using a peroxy acid and in turn forming peroxide intermediate that breaks down and forms the products.  In an ozonolysis, after the [3+2] between an ozone molecule and an alkene, the five membered ring breaks down to  a carbonyl and a carbonyl dioxide intermediate, which is called a “Criegee inermediate”.

Craig Taatjes and co-workers from Sandia National Laboratories have reported in Science on the observation of the Criegee intermediate by mass spec in the gas phase by reacting a methyl iodide radical and oxygen.

 

Science paper

Posted in Criegee rearrangement, Mass Spectrometry, Mechanistic, Methodology, Named Reactions | Leave a Comment »

TS analog complexed with protein and water

Posted by naturalproductman on January 17, 2012

Vern Schramm and co-workers at Albert Einstein College of Medicine have reported in JACS on the observation of a complex between a transition state analog and an enzyme, methylthioadenosine/S-adenosylhomocysteine nucleosidase through mass spectrometry.

transition state

JACS paper

Posted in Chemical Biology, Enzymes, Mass Spectrometry, Mechanistic, Proteins | Leave a Comment »

Evidence of iron-oxo

Posted by naturalproductman on October 13, 2011

Miquel Costas and co-workers at Universitat de Girona in Spain have reported in Nature Chemistry on the observation of an iron-oxo complex using mass spectrometry.

mass spec

Nature Chemistry paper

Posted in Computational, DFT, Iron, Mass Spectrometry, Mechanistic, Methodology, Transition Metal | Leave a Comment »

 
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