Ji-Jun Chen and co-workers at the Kunming Institute of Botany have reported in Org Lett on the isolation of sweriledugenin A.
Posted by naturalproductman on April 19, 2013
Benjamin List and co-workers have reported in JACS on their studies of cinchona alkaloid catalyzed asymmetric epoxidation of activated olefins.
Posted by naturalproductman on December 5, 2012
Scptt Rychnovsky and co-workers have reported in JACS on a clever way to determine the stereochemical configuration of a primary amine by using mass spectrometry. This may be useful when you only have a small amount of material.
Posted by naturalproductman on January 19, 2012
The Criegee rearrangement converts a tertiary alcohol into an alcohol and a ketone by using a peroxy acid and in turn forming peroxide intermediate that breaks down and forms the products. In an ozonolysis, after the [3+2] between an ozone molecule and an alkene, the five membered ring breaks down to a carbonyl and a carbonyl dioxide intermediate, which is called a “Criegee inermediate”.
Craig Taatjes and co-workers from Sandia National Laboratories have reported in Science on the observation of the Criegee intermediate by mass spec in the gas phase by reacting a methyl iodide radical and oxygen.
Posted by naturalproductman on January 17, 2012
Vern Schramm and co-workers at Albert Einstein College of Medicine have reported in JACS on the observation of a complex between a transition state analog and an enzyme, methylthioadenosine/S-adenosylhomocysteine nucleosidase through mass spectrometry.